The competition for the NFC West title is intensifying, and the Thursday Night Football game between the San Francisco 49ers and the Los Angeles Rams is a pivotal moment.

The 49ers (6-7) have faced a slew of injuries this season, yet as they approach Week 15, they remain in contention for their division title. Despite their injury woes, the team has also had to contend with some off-field issues, including wide receiver Deebo Samuel calling for more involvement in the offense, which may lead to adjustments in their strategy for the final stretch of the season.

The Rams (7-6) have similarly battled injuries that have impacted their performance, but their impressive 44-42 win against the Bills in Week 14 suggests a potential turnaround. Few defensive backfields in the league can contain the explosive pairing of Cooper Kupp and Puka Nacua, who combined for 254 receiving yards and two touchdowns in their latest matchup.

When it comes to coaching, Kyle Shanahan has a 10-5 record against Sean McVay, though McVay’s Rams bested the 49ers 27-24 in their previous meeting this September.

As the playoff race heats up, California is at the center of one of the NFL’s most competitive divisions. YSL News Sports will provide live updates, highlights, and more from the Week 15 Thursday Night Football contest between the Rams and the 49ers below.

Puka Nacua Impresses with a Stunning “Helmet Catch”

On the first play of the Rams’ next possession, quarterback Matthew Stafford targeted receiver Puka Nacua for a 7-yard pass. Nacua bobbled the ball briefly before securing it against a 49ers defender’s helmet as they both fell to the ground.

Unfortunately for Los Angeles, they couldn’t progress further and ended the drive with another three-and-out.

49ers 3, Rams 0: Jake Moody Opens the Scoring

After both teams went three-and-out, the 49ers moved into Rams territory, aided by a 33-yard catch-and-run by tight end George Kittle. Kicker Jake Moody capped the drive with a 53-yard field goal after the offense stalled at the Los Angeles 35-yard line.

With five minutes elapsed, the score stands at 3-0 in favor of the 49ers.

Game Start Time for 49ers vs. Rams

• Kickoff: 8:15 p.m. ET (5:15 PT)
• Venue: Levi’s Stadium, Santa Clara, California

The Rams are headed to Santa Clara to face off against the 49ers at their home stadium.

Broadcast Information for 49ers vs. Rams

• Live Streaming: Amazon Prime Video
• Television: Fox 11 (Los Angeles area) | Fox 2 (San Francisco area)

Thursday Night Football will exclusively be streamed on Amazon Prime Video for a national audience.

Fans in the Los Angeles area can watch the game on Fox 11, while those in San Francisco can tune into Fox 2.

Watch Thursday Night Football with a Prime Video subscription

Predictions for Rams vs. 49ers

Here’s how the YSL News Sports team predicts the outcome of the Rams versus 49ers matchup:

• Lorenzo Reyes: 49ers 28, Rams 23
• Tyler Dragon: Rams 26, 49ers 21
• Richard Morin: Rams 28, 49ers 27
• Jordan Mendoza: Rams 25, 49ers 24

Streaming for 49ers vs. Rams

• Live Stream: Amazon Prime Video

For viewers interested in watching the Thursday Night Football game between the 49ers and Rams, head over to Amazon Prime Video.

Catch Thursday Night Football with a Prime Video subscription

Announcers for ‘Thursday Night Football’ on Amazon Prime Video

The commentary team will feature Al Michaels as the play-by-play announcer and Kirk Herbstreit as the analyst, with Kaylee Hartung covering the sidelines and Terry McAulay as the rules analyst.

The pregame, halftime, and postgame shows on Prime Video will be hosted by Charissa Thompson, alongside former NFL players Ryan Fitzpatrick, Tony Gonzalez, Richard Sherman, and Andrew Whitworth as analysts.

Taylor Rooks will serve as the feature reporter for Prime Video’s coverage of Thursday Night Football, with Albert Breer delivering reports and analyses.

Inactives for 49ers vs. Rams

Key players Nick Bosa and Dre Greenlaw will both be active against the Rams. This will mark Greenlaw’s return after an unusual Achilles injury he sustained during Super Bowl 58.

On the offensive side for the 49ers, Isaac Guerendo will be available, but 11-time Pro Bowl tackle Trent Williams will not be playing.

• QB Joshua Dobbs
• LT Trent Williams
• DL Khalil Davis
• S Malik Mustapha
• RB Israel Abanikanda
• CB Rock Ya-Sin

Inactives for Rams vs. 49ers

• RB Cody Schrader
• LB Brennan Jackson
• OL Dylan McMahon
• OL Warren McClendon Jr.

Betting Odds for Rams vs. 49ers

The odds favor the 49ers

The BetMGM NFL odds suggest that the 49ers are favored to win against the Rams. If this matchup doesn’t pique your interest, you can also find expert picks and top betting options for all NFL games this week.

• Spread: 49ers (-2.5)
• Moneyline: 49ers (-150); Rams (+125)
• Over/under: 48.5

Best Bets for Thursday Night Football

Want to spice up the “TNF” game? Here are some great betting plays for tonight’s 49ers vs. Rams game. All odds are current as of Thursday from BetMGM.

• Kyren Williams OVER 73.5 rushing yards (-115);
• Matthew Stafford UNDER 0.5 rushing yards (-120);
• Kyle Juszczyk anytime TD (+750)

Injury Update on Isaac Guerendo

According to ESPN’s Adam Schefter, Isaac Guerendo intends to participate against the Rams on Thursday night.

He exited Sunday’s victory with what Coach Kyle Shanahan described as a potential foot sprain. Guerendo appeared relaxed about his readiness for “Thursday Night Football,” mentioning to NBC Sports Bay Area post-game that the team was merely exercising caution.

49ers to Involve Deebo Samuel More

The 49ers perform significantly better when they incorporate various strategies to utilize Deebo Samuel, particularly in situations where key players like Christian McCaffrey and Brandon Aiyuk are absent. Samuel stands as only the second player in NFL history to achieve over 4,000 receiving yards and more than 1,000 rushing yards in the first five seasons of his career.

If the 49ers aim to overcome the Rams, improve their standing in the NFC West, and position themselves for a playoff push, Samuel must play a pivotal role in their offense. This realization seems apparent to the 49ers, as indicated by Samuel’s recent deletion of a social media post. — Tyler Dragon

Location of 49ers vs. Rams Game

The “TNF” clash between the 49ers and the Rams will be held at Levi’s Stadium in Santa Clara, California.

Opened in 2014, Levi’s Stadium was the venue for Super Bowl 50, where the Denver Broncos defeated the Carolina Panthers. It is also set to host Super Bowl 60 on February 8, 2026.

Weather Forecast for Rams vs. 49ers

The temperature at Levi’s Stadium during the game is expected to be in the mid-50s, as reported by AccuWeather. There is a likelihood of rain affecting the game.

NFC West Standings

As it stands, the Seahawks are leading the NFC West, but the division remains competitive as the season progresses.

1. Seattle Seahawks (8-5)
2. Los Angeles Rams (7-6)
3. Arizona Cardinals (6-7)
4. San Francisco 49ers (6-7)

NFC West Tiebreaker Situation for Division Title

Los Angeles Rams

The Rams hold the most favorable chance to challenge the Seahawks for the division. They could potentially achieve a head-to-head sweep against the Seahawks, which could be critical in resolving a two-team tiebreaker. Furthermore, they have the most remaining divisional games amongst all competitors, increasing their chances of enhancing their 2-1 divisional record.

Securing four divisional wins would enable the Rams to clinch that tiebreaker if they manage to defeat the Seahawks in Week 18.

San Francisco 49ers

No other team faces a greater challenge than the 49ers in their quest for the NFC West title.

San Francisco currently has only one divisional victory, and the best they can hope for in their upcoming two head-to-head matches is to split with the Rams and Cardinals, both of whom have already taken them down once this season.

49ers Playoff Chances

The 49ers have a +1000 odds of making the playoffs heading into Week 15, translating to a 9.09% probability of securing a postseason spot, as per BetMGM Sportsbook.

Remaining Schedule for the 49ers

According to Tankathon, the 49ers’ last four opponents have a combined winning percentage of .596, making it one of the toughest schedules remaining in the NFL.

Here’s a complete view of San Francisco’s upcoming matches:

• Week 15: vs. Los Angeles Rams (7-6)
• Week 16: at Miami Dolphins (6-7)
• Week 17: vs. Detroit Lions (12-1)
• Week 18: at Arizona Cardinals (6-7)

Remaining Schedule for the Rams

With a combined winning percentage of .442 for their last four opponents, the Rams rank 21st in terms of remaining schedule difficulty across the NFL.

Here’s a complete view of Los Angeles’ upcoming matches:

• Week 15: at San Francisco 49ers (6-7)
• Week 16: at New York Jets (3-10)
• Week 17: vs. Arizona Cardinals (6-7)
• Week 18: vs. Seattle Seahawks (8-5)

NFL Teams with Most Super Bowl Wins

The New England Patriots and Pittsburgh Steelers are tied for the highest number of Super Bowl victories, each with six titles.

The 49ers have made eight Super Bowl appearances and secured five championships, with their last title triumph occurring during the 1994 season in Super Bowl XXIX.

The Rams have reached the Super Bowl five times, winning two, with their latest victory in Super Bowl 56 against the Cincinnati Bengals.

Teams with the most Super Bowl titles:

• New England Patriots — 6
• Pittsburgh Steelers — 6
• Dallas Cowboys — 5
• San Francisco 49ers — 5
• Green Bay Packers — 4
• Kansas City Chiefs — 4
• New York Giants — 4