Decline in memory and cognitive functions is commonly associated with Alzheimer’s disease (AD). In addition to memory problems, individuals with AD may also exhibit emotional symptoms like agitation, depression, lack of interest, and sleep disturbances. A recent study suggests that the underlying pathology of AD could directly contribute to these emotional and behavioral symptoms. Furthermore, the research indicates that mental health issues tend to worsen as individuals with AD experience decline in memory and cognitive abilities.
Decline in memory and cognitive functions is commonly associated with Alzheimer’s disease (AD). In addition to memory problems, individuals with AD may also exhibit emotional symptoms like agitation, depression, lack of interest, and sleep disturbances.
A recent study conducted by researchers at Boston University Chobanian & Avedisian School of Medicine has revealed that the underlying pathology of AD could be a direct contributor to emotional and behavioral symptoms. The study also found that as individuals with AD experience decreased memory and cognitive abilities, their mental health tends to deteriorate.
The lead author of the study, Michael Alosco, PhD, who is an associate professor of neurology, emphasized the significance of mental health symptoms in individuals with AD, highlighting the impact they can have on the quality of life for patients and their families. Alosco stressed the importance of understanding the root causes of these early symptoms to effectively manage them.
The researchers analyzed data from participants in the National Alzheimer’s Coordinating Center, a prominent national database used for AD research. The participants underwent testing involving analysis of cerebrospinal fluid (CSF) for AD markers, memory assessments, dementia severity evaluations, and assessment of mental health symptoms by caregivers or family members. Statistical analysis was then conducted on the data.
The findings revealed that higher levels of AD-associated proteins, as indicated by CSF markers, were predictive of various mental health symptoms, which could not solely be explained by cognitive symptoms. This suggests that mental health symptoms in AD may arise directly from underlying brain changes related to the disease. Moreover, increased mental health symptoms and memory difficulties were associated with greater challenges in daily functioning, particularly in individuals with dementia.
The research indicated that mental health issues in individuals with AD may stem from various factors in the early stages of the disease but are more likely to be directly linked to AD progression as the disease advances. The lead author, Brandon Frank, PhD, an assistant professor of neurology, highlighted the importance of a holistic approach to treatment for individuals with AD. He suggested that treatments such as cognitive rehabilitation could not only help individuals cope with memory difficulties but also improve their overall well-being.
The study detailing these findings has been published online in the Journal of Alzheimer’s Disease.
