Last weekend was crucial for every team with a 2-2 record. While the difference between 2-3 and 3-2 might be just one game, the perception of each outcome is significantly different. As we enter Week 6, it’s time for the teams that lost last week to find their rhythm as the midseason approaches.

Week 6 begins with an exciting matchup on Thursday night featuring the San Francisco 49ers against the Seattle Seahawks. The 49ers come off a tough loss to the Arizona Cardinals, and two of their three losses occurred after they had established significant leads. Although head coach Kyle Shanahan has gained a reputation for letting leads slip away, the 49ers remain contenders for the Super Bowl and need to address their challenges if they aim to succeed in the NFC West.

On Sunday, the Jacksonville Jaguars will make their return to London to face the Chicago Bears. Later that evening, the Cincinnati Bengals will go head-to-head with the New York Giants, who are coming off an impressive win over the Seahawks. Monday Night Football will close out the week with an AFC East clash between the New York Jets and the Buffalo Bills.

Check out the complete odds and our expert forecasts for the matchups coming up this week.

If you’re new to sports betting, YSL News readers can access exclusive promotions and bonus codes available through top online sportsbooks and betting sites. Below are the NFL betting odds for Week 6, sourced from BetMGM NFL odds.

NFL Week 6 Predictions

• Seahawks vs. 49ers
• Bears vs. Jaguars
• Ravens vs. Commanders
• Packers vs. Cardinals
• Patriots vs. Texans
• Saints vs. Buccaneers
• Eagles vs. Browns
• Titans vs. Colts
• Broncos vs. Chargers
• Raiders vs. Steelers
• Panthers vs. Falcons
• Cowboys vs. Lions
• Giants vs. Bengals
• Jets vs. Bills

NFL Week 6 Point Spreads

• San Francisco 49ers (-3.5) at Seattle Seahawks
• Jacksonville Jaguars (+2.5) vs. Chicago Bears
• Washington Commanders (+6.5) at Baltimore Ravens
• Arizona Cardinals (+5) at Green Bay Packers
• Houston Texans (-7) at New England Patriots
• Tampa Bay Buccaneers (-3.5) at New Orleans Saints
• Cleveland Browns (+8.5) at Philadelphia Eagles
• Indianapolis Colts (-1) at Tennessee Titans
• Los Angeles Chargers (-3) at Denver Broncos
• Pittsburgh Steelers (-3) at Las Vegas Raiders
• Atlanta Falcons (-6) at Carolina Panthers
• Detroit Lions (-3) at Dallas Cowboys
• Cincinnati Bengals (-3.5) at New York Giants
• Buffalo Bills (-2.5) at New York Jets

NFL Week 6 Moneylines

• San Francisco 49ers (-190) at Seattle Seahawks (+155)
• Jacksonville Jaguars (+120) vs. Chicago Bears (-145)
• Washington Commanders (+240) at Baltimore Ravens (-300)
• Arizona Cardinals (+190) at Green Bay Packers (-250)
• Houston Texans (+240) at New England Patriots (-300)
• Tampa Bay Buccaneers (-200) at New Orleans Saints (+165)
• Cleveland Browns (+350) at Philadelphia Eagles (-450)
• Indianapolis Colts (-115) at Tennessee Titans (-105)
• Los Angeles Chargers (-165) at Denver Broncos (+140)
• Pittsburgh Steelers (-155) at Las Vegas Raiders (+130)
• Atlanta Falcons (-275) at Carolina Panthers (+220)
• Detroit Lions (-165) at Dallas Cowboys (+140)
• Cincinnati Bengals (-185) at New York Giants (+150)
• Buffalo Bills (-145) at New York Jets (+120)

NFL Week 6 Over/Under

• San Francisco 49ers at Seattle Seahawks: 47.5
• Jacksonville Jaguars vs. Chicago Bears: 44.5
• Washington Commanders at Baltimore Ravens: 52.5
• Arizona Cardinals at Green Bay Packers: 49.5
• Houston Texans at New England Patriots: 38
• Tampa Bay Buccaneers at New Orleans Saints: 41.5
• Cleveland Browns at Philadelphia Eagles: 43.5
• Indianapolis Colts at Tennessee Titans: 42.5
• Los Angeles Chargers at Denver Broncos: 35.5
• Pittsburgh Steelers at Las Vegas Raiders: 36.5
• Atlanta Falcons at Carolina Panthers: 47.5
• Detroit Lions at Dallas Cowboys: 52.5
• Cincinnati Bengals at New York Giants: 49
• Buffalo Bills at New York Jets: 41