A recent study has identified a specific gene that significantly impacts longevity, potentially leading to new treatments.
Sleeping well, fasting, exercising, enjoying green porridge, consuming black coffee, and maintaining a vibrant social life.
There is a wealth of information available on achieving a long and fulfilling life. Scientists are diligently exploring the reasons behind why some individuals enjoy longer lifespans than others and how we can maximize our extended years.
Researchers from the Center for Healthy Aging within the Department of Cellular and Molecular Medicine at the University of Copenhagen have made a significant discovery. They found that a specific protein called OSER1 plays a crucial role in influencing longevity.
“We have identified this protein that can enhance lifespan. It is a new pro-longevity factor and is found in various species, including fruit flies, nematodes, silkworms, and humans,” explains Professor Lene Juel Rasmussen, the lead author of the study.
Since this protein is found across multiple species, the researchers believe their findings are also relevant to humans:
“We pinpointed a protein that is commonly found in different animal models as well as humans. We examined these proteins and correlated the data from the animal studies with the human cohort involved in the research. This helps us determine whether the findings are applicable to humans,” states Zhiquan Li, the primary author of the study, adding:
“If a gene is only found in animal models, it can be challenging to apply to human health. That’s why we initially focused on potential longevity proteins present in a wide range of organisms, including humans. Ultimately, we aim to uncover human longevity genes for potential treatments and drug development.”
Opening doors to new treatments
During their investigation, the researchers discovered OSER1 while examining a broader group of proteins regulated by a key transcription factor known as FOXO, which serves as a longevity regulatory center.
“We identified 10 genes that, when we altered their expression, impacted longevity. We chose to concentrate on one particularly influential gene, the OSER1 gene,” shares Zhiquan Li.
When a gene is linked to a reduced lifespan, it elevates the risk for premature aging and related diseases. Thus, understanding how OSER1 operates within cells and in preclinical animal models is essential for grasping human aging and overall health.
“Our current focus is on revealing the function of OSER1 in humans, but the limited existing research poses a challenge since very few studies have addressed this topic so far. This research is the first to show that OSER1 is a key regulator of aging and longevity. We aspire to shed light on the specific age-related diseases and aging processes influenced by OSER1,” remarks Zhiquan Li.
The researchers also hope that recognizing and characterizing OSER1 will lead to new drug targets for age-related conditions, including metabolic diseases, cardiovascular issues, and neurodegenerative disorders.
“Thus, uncovering this new pro-longevity factor enhances our understanding of longevity in humans,” concludes Zhiquan Li.
