It’s that time again—get ready for another season of “Grey’s Anatomy.”

The 21st season of ABC’s enduring medical drama is set to launch this Thursday following a summer break.

This new episode is anticipated to follow the events of the Season 20 finale, in which Dr. Meredith Grey (Ellen Pompeo) decided to leave Grey Sloan Memorial Hospital to focus on her research into Alzheimer’s disease. During this time, several staff members were let go, including Amelia Shepherd (Caterina Scorsone), Owen Hunt (Kevin McKidd), and Chief of Surgery Teddy Altman (Kim Raver).

Season 21 marks the first season following the conclusion of “Station 19,” a firefighter series that regularly intersected with “Grey’s.” Jason George, who portrayed Ben Warren for seven seasons on the firefighter show, will be making a return in a recurring role as Miranda Bailey’s (Chandra Wilson) husband.

Here’s everything you need to know about Season 21 of “Grey’s Anatomy.”

When is ‘Grey’s Anatomy’ Season 21 starting?

“Grey’s Anatomy” Season 21 will premiere on Thursday, September 26, at 10 p.m. on ABC.

Where to watch ‘Grey’s Anatomy’ Season 21

All previous 20 seasons of the show are available for streaming on both Netflix and Hulu. Typically, Netflix adds new seasons of “Grey’s Anatomy” shortly after they conclude, and Season 21 is expected to follow this pattern.

How many episodes are in Season 21?

Season 21 of “Grey’s Anatomy” will feature 18 episodes, which is an increase from the 10 episodes offered in Season 20.

The previous season was shorter due to the strikes involving actors and writers that took place last year. The medical drama usually debuts its new seasons in the fall and wraps up in the spring.

Is Meredith Grey returning to ‘Grey’s Anatomy’?

According to Deadline, Meredith Grey will be back for at least seven of the 18 episodes in Season 21.

In August 2022, Pompeo revealed that her appearances would be limited from Season 19 onwards but she continues to play a significant role behind the scenes as an executive producer, and she provides her iconic voiceover narrations throughout each episode.

When did ‘Grey’s Anatomy’ begin?

“Grey’s Anatomy” premiered its first episode, titled “A Hard Day’s Night,” on ABC on March 27, 2005.

The pilot episode showcased the inaugural day of five surgical interns at Seattle Grace Hospital and the series has since explored the personal and professional journeys of staff at what is now known as Grey Sloan Memorial Hospital.