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Scientists have generated human stem cell models which contain notochord -- a tissue in the developing embryo that acts like a navigation system, directing cells where to build the spine and nervous system (the trunk). Scientists at the Francis Crick Institute have generated human stem cell models1 which, for the first time, contain notochord --
HomeDiseaseCognitiveUnlocking the Human Brain: Understanding the Switching Mechanism for Survival Tasks

Unlocking the Human Brain: Understanding the Switching Mechanism for Survival Tasks

 

In a recent study published in the journal PLOS Biology, researchers have shed light on the role of the hypothalamus in facilitating the switch between different survival behaviors in the human brain. This small brain region is known for regulating basic functions like body temperature, hunger, and sleep, but it also plays a crucial role in transitioning between activities such as hunting and escaping from threats.

Past research in animals has suggested the importance of the hypothalamus in behavior switching, but its role in humans remained unclear due to technical limitations. To address this gap, the researchers employed artificial intelligence techniques to analyze brain scans of 21 participants engaged in a survival game while inside an fMRI scanner. During the game, participants had to alternate between hunting and evading a predator through controlling an avatar.

By developing a computational model to interpret movement patterns associated with hunting and escaping behaviors, the team identified distinct neural activity patterns in the hypothalamus and its connected brain regions. These patterns were found to correlate with the switching of survival behaviors and even predicted participants’ performance in subsequent tasks. Interestingly, this link was specific to transitioning between hunting and escaping actions, highlighting the unique role of the hypothalamus in coordinating such essential behaviors.

The study underscores the significance of the hypothalamus in orchestrating the brain’s ability to switch between crucial survival tasks, a mechanism that has likely evolved to enhance human adaptability and survival in challenging environments.

The researchers emphasize, “Cutting-edge research utilizing advanced imaging and computational methods reveals the pivotal role of the human hypothalamus in facilitating the switch between survival behaviors like hunting and escaping, offering new insights into how this brain region collaborates with others to manage these critical strategies.”