Researchers at the University of Surrey discovered that the interactions between T and B cells should be the main focus for scientists in order to develop more effective treatments for autoimmune disorders like rheumatoid arthritis. The study by Systems Biology experts revealed that our metabolism may have a significant impact on the balance of T and B cells, which can result in autoimmune diseases. Additionally, the study provided evidence that the interaction between T and B cells is a crucial factor in the development of autoimmune disorders.experience changes in their behavior due to shifts in the body’s energy processing. Dr. Matteo Barberis, the study’s lead author from the School of Biosciences, suggests a new approach to treating autoimmune diseases by focusing on the metabolism of these immune cells. Understanding how T and B cells interact and change their behavior as a result of aging can lead to more effective treatments. This approach combines the study of inflammation and immunometabolism, examining how the immune system uses energy and the impact of aging. T and B cells, specialized white blood cells, are at the center of these changes.T cells and B cells are essential components of our immune system. T cells are responsible for identifying and combating infected cells, while B cells produce antibodies that can deactivate harmful invaders, such as viruses and bacteria. By working together, T and B cells can fulfill the metabolic requirements needed at each stage of their development.
The research team carefully analyzed existing literature in various fields, including inflammation and immunometabolism, to gain a comprehensive understanding of the processes involved. This involved integrating metabolic, signaling, and epigenetic pathways.
Dr. Matteo Barberis explained, “This approach aims to develop therapeutic treatments for autoimmune conditions by understanding the interconnected nature of metabolic, signaling and epigenetic pathways.”A new approach to treating autoimmune disorders involves repurposing drugs to target both the immune system and metabolism at the same time. This approach shows promise for better management of diseases like lupus and multiple sclerosis.
