In a randomized clinical trial, giving the clot-busting medication alteplase up to 24 hours after stroke symptoms first appeared increased the odds of better recovery by 50% compared to those who received standard antiplatelet treatment. The clot-dissolving medication, alteplase, improved stroke patients' recovery by more than 50% when given up to 24 hours after the
Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use
In a randomized clinical trial, giving the clot-busting medication alteplase up to 24 hours after stroke symptoms first appeared increased the odds of better recovery by 50% compared to those who received standard antiplatelet treatment. The clot-dissolving medication, alteplase, improved stroke patients' recovery by more than 50% when given up to 24 hours after the
In a randomized clinical trial, giving the clot-busting medication alteplase up to 24 hours after stroke symptoms first appeared increased the odds of better recovery by 50% compared to those who received standard antiplatelet treatment. The clot-dissolving medication, alteplase, improved stroke patients' recovery by more than 50% when given up to 24 hours after the
Scientists have identified genetic components in bats that provide insight into their immune systems. Five years removed from the COVID-19 outbreak, scientists around the world are still studying its effects and, more importantly, ways those effects can be mitigated in the future. An international team of researchers may have just found a critical clue in
Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use
Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug discovery and protein engineering. Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments -- water, lipid membranes, or other condensed phases
A new molecular imaging technique -- 18F-FAPI PET -- can detect the first signs of tissue remodeling in patients with pulmonary arterial hypertension (PAH), providing physicians with an early marker for disease progression. This approach has the potential to pave the way for more personalized management of PAH, offering more timely interventions to improve patient
The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the development of innovative therapeutic strategies to counter osteoporosis. Their research findings reveal the intrinsic role of Fam102a in the nuclear trafficking of key transcription factors-regulatory proteins
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally, posing a particularly significant threat to people with HIV (PWH). To address this, CVD prevention plans rely on prediction models like atherosclerotic cardiovascular disease (ASCVD) risk scores to estimate the risk of heart disease. However, previous studies have called into question whether these
Osteoarthritis disproportionally affects postmenopausal women, and a biological mechanism for why this occurs has been largely unkown, hindering development of effective treatments. That is in part because of a lack of reliable animal models of menopause. In a new study researchers used a mouse model of menopause to uncover a novel mechanism for OA onset
In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant, treatment with trastuzumab emtansine (T-DM1) reduced the long-term risk of death or invasive disease by 46% and improved survival compared to trastuzumab alone, according to the final results of the phase 3 KATHERINE clinical trial. In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant
Researchers have made an important discovery in the field of asthma research, identifying a new population of immune cells that may play a crucial role in the severity of asthma symptoms. Researchers at McMaster University have made an important discovery in the field of asthma research, identifying a new population of immune cells that may
Tourette syndrome is currently diagnosed about three times more frequently in males than in females. A new study finds that female individuals are less likely to be diagnosed with the syndrome, take longer to receive a diagnosis and are older when they are diagnosed than male individuals. Tourette syndrome is currently diagnosed about three times
A new study explores the effects of both recent and lifetime cannabis use on brain function during cognitive tasks. The study, the largest of its kind ever to be completed, examined the effects of cannabis use on over 1,000 young adults aged 22 to 36 using brain imaging technology. The researchers found that 63% of
Researchers have achieved total chemical synthesis of the psychoactive compound ibogaine and its analogs from pyridine. The discovery will make it easier to explore the therapeutic possibilities of ibogaine. Ibogaine -- a psychoactive plant derivative -- has attracted attention for its anti-addictive and anti-depressant properties. But ibogaine is a finite resource, extracted from plants native
A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease modeling, soft robotics and more, according to researchers. A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease modeling, soft robotics and more, according to researchers at Penn State. Materials created up to this point
The researchers showed that when curcumin is intentionally given to bacteria as food and then activated by light, it can trigger deleterious reactions within these microbes, eventually killing them. This process, they demonstrated, reduces the number of antibiotic-resistant strains and renders conventional antibiotics effective again. In 2017, a tragic incident unfolded in a Nevada hospital.
