Autoimmune

Researchers have revealed a novel association between chromosome 18q deletion syndrome and late-onset combined immunodeficiency (LOCID). Their finding challenges the previously held notion that 18q deletion syndrome only involves humoral immunodeficiency affecting B cells and antibody production. Moreover, the study highlights the need for regular immune function testing in 18q deletion syndrome patients for early

Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease. Northwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as

Researchers have provided new insights into the lasting effects of chronic Hepatitis C virus (HCV) infection on the immune system, even after the disease has been successfully treated. The research team has discovered that traces of 'epigenetic scars' remain in regulatory T cells and exhibit sustained inflammatory properties long after the virus is cleared from

Recently, scientists found that some people who suffered from COVID-19 had auto-antibodies targeting their own type 1 interferons, which are important immune signaling proteins. Now, researchers conducted an in-depth study on 123 Japanese COVID-19 patients to clarify just how common these auto-antibodies are among severe cases and how they affect the immune system. Their findings

Researchers have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma. The discoveries were made possible by a newly developed technology they call ReapTEC. The new T cell atlas is publicly available and should help in the development of new drug

Bacteria are experts at evolving resistance to antibiotics. One resistance strategy is to cover their cell walls in sticky and gooey biofilm that antibiotics cannot penetrate. A new discovery could put a stop to this strategy. Antibiotic resistant bacteria are experts in evolving new strategies to avoid being killed by antibiotics. One such bacterium is

A new method of precisely targeting troublesome cells for death using light could unlock new understanding of and treatments for cancer and inflammatory diseases. A new method of precisely targeting troublesome cells for death using light could unlock new understanding of and treatments for cancer and inflammatory diseases, University of Illinois Urbana-Champaign researchers report. Inflammatory

A team identifies target protein regulating autoimmune disease lupus. A research team of Professor Yoontae Lee and Jiho Park, a PhD candidate, from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH) recently discovered that a particular protein promotes the development of systemic lupus erythematosus (SLE). The study was published in

An innovative combination of methods to identify and study how macrophages function could potentially revolutionize the diagnosis and treatment of various diseases. Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair. Understanding how these cells are activated in different scenarios is important for developing new medical treatments.

Researchers determined the Foxp3 protein is actually a cofactor, hijacking DNA-binding proteins responding to the immunological environment of the T cell. Based on the type of response needed, different factors are expressed, which is the driving force for Foxp3 to suppress an immune response. The protein Foxp3 is vital to the function of immune cells

Of more targeted and effective treatments for neuromyelitis optica spectrum disorder. The study's focus on understanding the immune system's response to treatment sets it apart, offering valuable insights that could potentially revolutionize the way this condition is managed. This research has the potential to lead to groundbreaking advancements in the field of autoimmune disease treatment, offering hope to patients and healthcare professionals alike

A surprising discovery has revealed that immune system cells called macrophages are at the heart of the intricate link between obesity and cancer. This revelation provides a crucial understanding of how obesity can heighten cancer risk and bolster responses to immunotherapy. This groundbreaking insight sheds light on the pivotal role macrophages play in this complex relationship, offering new potential for treating both obesity-related cancer and immunotherapy responses