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First-Ever Discovery of a Human Odorant Receptor for Geosmin Unveiled

Geosmin is a volatile compound of microbial origin with a distinct 'earthy' to 'musty' odor that can affect the quality of water and food. A research team has now identified and characterized the human odorant receptor for geosmin for the first time. Geosmin is a volatile compound of microbial origin with a distinct "earthy" to
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Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

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Revolutionizing Drug Screening: The Power of Electrical Impedance Tomography for Extracellular Voltage Activation

Recently, researchers developed a non-invasive method combining electrical impedance tomography and extracellular voltage activation to evaluate drug effects on ion channels. The resulting printed circuit board sensor allows real-time monitoring of how newly developed drugs can affect ion flow in channels, providing a cost-effective and accurate alternative to traditional methods like patch-clamp techniques and paving
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Unlocking Precision Medicine: The Hidden Impact of Proteins on Existing Medications

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First-Ever Discovery of a Human Odorant Receptor for Geosmin Unveiled

Geosmin is a volatile compound of microbial origin with a distinct 'earthy' to 'musty' odor that can affect the quality of water and food. A research team has now identified and characterized the human odorant receptor for geosmin for the first time. Geosmin is a volatile compound of microbial origin with a distinct "earthy" to

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First-Ever Discovery of a Human Odorant Receptor for Geosmin Unveiled

Geosmin is a volatile compound of microbial origin with a distinct 'earthy' to 'musty' odor that can affect the quality of water and food. A research team has now identified and characterized the human odorant receptor for geosmin for the first time. Geosmin is a volatile compound of microbial origin with a distinct "earthy" to

Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

Revolutionizing Drug Screening: The Power of Electrical Impedance Tomography for Extracellular Voltage Activation

Recently, researchers developed a non-invasive method combining electrical impedance tomography and extracellular voltage activation to evaluate drug effects on ion channels. The resulting printed circuit board sensor allows real-time monitoring of how newly developed drugs can affect ion flow in channels, providing a cost-effective and accurate alternative to traditional methods like patch-clamp techniques and paving
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Cellular Responses to Physical Stress: How Cells Adapt Under Pressure

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Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on

Challenges of Expiring Medications on Long Space Missions: Solutions for Astronaut Health

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A new study shows that over half of the medicines stocked in space -- staples such as pain relievers, antibiotics, allergy medicines, and sleep aids -- would expire before astronauts could return to Earth. Medications used by astronauts on the International Space Station might not be good enough for a three-year journey to Mars. A

Research Reveals Warehousing Industry’s Role in Rising Health-Harming Pollutants

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A new study shows an average 20-percent spike of nitrogen dioxide polluting the air for communities located near huge warehouses. And people of color are harder hit. America's demand for products delivered to the doorstep has led to a dramatic increase in e-commerce and the warehousing industry. A first-of-a-kind study now shows that people living

AI-Powered Robotics: Training Dogs to Respond to Their Masters

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An international collaboration seeks to innovate the future of how a mechanical man's best friend interacts with its owner, using a combination of AI and edge computing called edge intelligence. The overarching project goal is to make the dog come 'alive' by adapting wearable-based sensing devices that can detect physiological and emotional stimuli inherent to

Exploring the Future: Pioneering the Cellular Frontier in Biotechnology

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Scientists use a multimodal approach that combines hard X-ray computed tomography and X-ray fluorescence imaging to see the structure and chemical processes inside of a single cell. Every plant, animal, and person is a rich microcosm of tiny, specialized cells. These cells are worlds unto themselves, each with their own unique parts and processes that

Revolutionary Dual-Action Antibiotic: Tackling Bacterial Resistance Effectively

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New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance. A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago. For a new paper

Unlocking Cancer Treatment: How Tumor Suppressor Protein Par-4 Induces Unique Cell Death Pathway

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A team of researchers has discovered that the tumor suppressor protein Prostate apoptosis response-4 (Par-4) can cause a unique type of cell death called ferroptosis in human glioblastoma -- the most common and aggressive type of brain tumor -- while sparing healthy cells. This new understanding has the potential to inform the development of novel

Can Smart Guide RNAs Revolutionize Personalized Medicine? Exploring the Future of Tailored Treatments

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Scientists utilize logic gate-based decision-making to construct circuits that control genes. Guides typically assist tourists with directions, but the experience could be greatly enhanced if they offered personalized services tailored to individual interests. Recently, researchers have transformed guide RNAs, which direct enzymes, into a smart RNA capable of controlling networks in response to various signals.

Revolutionizing Medicine: Scientists Print Organs on Demand with Voxel Building Blocks

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Scientists are bioprinting 3D structures with a material that is a close match for human tissue, paving the way for true biomanufacturing. A research team at the University of Virginia School of Engineering and Applied Science has developed what it believes could be the template for the first building blocks for human-compatible organs printed on

Enhancing CAR T Cell Therapy: The Impact of CD5 Knockout on Anti-Tumor Efficacy

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The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study. The effectiveness of CAR T cell therapy against a variety of

Revolutionary Foldable Pouch Actuator Enhances Finger Extension in Soft Rehabilitation Gloves

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Hand rehabilitation research has markedly benefited from the introduction of soft actuators in gloves. However, existing soft rehabilitation glove designs have several limitations in finger movements. In this regard, researchers recently succeeded in adding finger straightening or extension to soft rehabilitation gloves through a novel foldable pouch actuator without compromising the already existing functionality of

Revolutionizing Immunity: How B Cell Biohacking Creates Custom Antibodies

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Scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes. USC scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody
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