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Unlocking Precision Medicine: The Hidden Impact of Proteins on Existing Medications

Fewer side effects, improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level. Researchers have now succeeded in mapping the interactions of 144 active substances with around 8,000 proteins. The results could help

Unraveling the Link Between Obesity and Heart Failure

A new small study has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF). A new small study led by Johns Hopkins Medicine researchers and published July 25th in the journal Nature Cardiovascular Research has revealed the impact of

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Unlocking Precision Medicine: The Hidden Impact of Proteins on Existing Medications

Fewer side effects, improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level. Researchers have now succeeded in mapping the interactions of 144 active substances with around 8,000 proteins. The results could help

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Unlocking Precision Medicine: The Hidden Impact of Proteins on Existing Medications

Fewer side effects, improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level. Researchers have now succeeded in mapping the interactions of 144 active substances with around 8,000 proteins. The results could help

The Next Generation of Cheese: Embracing Animal-Free Innovations

Companies and institutes are currently working on biotechnological processes for the production of 'dairy products' without the use of cows: In so-called precision fermentation, egg and milk proteins are produced with the help of bacteria, yeasts or other fungi. This results in foods such as milk or cheese with a familiar flavor and texture. Supporters

Unraveling the Link Between Obesity and Heart Failure

A new small study has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF). A new small study led by Johns Hopkins Medicine researchers and published July 25th in the journal Nature Cardiovascular Research has revealed the impact of
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Revolutionizing Human Remains Identification with Craniofacial Superimposition

Researchers propose an improvement in the identification of human remains using craniofacial superimposition. The forensic identification technique is based on the analysis of a skull (post-mortem) and photographs of the person's face (ante-mortem). It represents a major step in making objective decisions that are based on the ability to quantify the probability that a skull

Caregiver Stress: Impact of Cell Damage on Mental and Physical Health

Researchers have found that intense stress can be felt at the cellular level and is linked to negative physical and mental health effects. It's no secret that the caregivers of spouses with memory impairment face enormous amounts of stress. Researchers at Rice University have found that this intense pressure can be felt at the cellular

Shocking Study: UK Adolescents Consuming Two-Thirds of Calories from Ultra-Processed Foods

Adolescents consume around two-thirds of their daily calories from ultra-processed foods (UPFs) new research has found. The study found that UPF consumption was highest among adolescents from deprived backgrounds, those of white ethnicity, and younger adolescents. Adolescents consume around two-thirds of their daily calories from ultra-processed foods (UPFs) new research from the Universities of Cambridge

Revolutionizing Infant Genetics Research: A Game-Changer for Lives

Investment in research into genetics could dramatically improve educational policies and understanding of parenting in ways that could help all children, according to a new paper. Investment in research into genetics could dramatically improve educational policies and understanding of parenting in ways that could help all children, according to a new paper led by the

E. coli Variant: Antimicrobial Resistance in Dogs and Humans

Researchers studying antimicrobial-resistant E. coli -- the leading cause of human death due to antimicrobial resistance worldwide -- have identified a mechanism in dogs that may render multiple antibiotic classes ineffective. Researchers studying antimicrobial-resistant E. coli -- the leading cause of human death due to antimicrobial resistance worldwide -- have identified a mechanism in dogs

Research suggests protein isoform inhibitors may provide a safe alternative to opioids

Researchers have identified a new way to make opioids safer, increasing the pain-relieving properties of opioids while decreasing unwanted side effects through the spinal inhibition of a Heat shock protein 90 isoform. Researchers at the University of Arizona Health Sciences identified a new way to make opioids safer, increasing the pain-relieving properties of opioids while

Nighttime Routine: Evening Activity Ideas for Better Sleep

Rigorous exercise before bed has long been discouraged, but researchers have now found short bursts of light activity can lead to better sleep. Rigorous exercise before bed has long been discouraged, but University of Otago researchers have found short bursts of light activity can lead to better sleep. In a world first study, published in

Intensive Farming Risks: Could it Lead to New Pandemics?

Industrialized farming is often thought to reduce the risk of zoonotic diseases because of better control, biosecurity and separation of livestock. A new study examines the effect of social and economic factors -- which are often overlooked in traditional assessments. Intensive livestock farming could raise the risk of new pandemics, researchers have warned. Industrialised farming

Study: Global Adolescent Fertility Decline Countered by Rising Teen Births in Sub-Saharan Africa

A new report highlights a troubling trend: while global adolescent fertility rates have significantly declined, sub-Saharan Africa is experiencing an increase in teen births. This region's share of global adolescent births surged from 12 percent in 1950 to 47 percent in 2020 and is projected to reach a clear majority -- a full 67 percent

Timing is everything: Study finds link between bowel movement frequency and overall health

Researchers examined the clinical, lifestyle, and multi-omic data of more than 1,400 healthy adults. How often people poop, they found, can have a large influence on one's physiology and health. Everybody poops, but not every day. New research by the Institute for Systems Biology (ISB) suggests bowel movement frequency is linked to long-term health. An

Maximizing Delivery Efficiency: Transporting Precious Cargo with the Body’s Own System

Delivery systems in body continuously move materials between cells. Hijacking these systems allowed scientists to improve loading and delivery of therapeutic proteins. Biophysical principles could be used to enable more cost-effective loading of biological cargo into cell-derived delivery systems. Engineered molecules loaded up to 240 times more protein than other loading methods. Each cell in

Harnessing Big Data: Uncovering New Antimicrobials

Researchers have developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets, providing clues for discovering alternatives to traditional antibiotics. Researchers have developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets, providing clues for discovering alternatives to traditional antibiotics. The study, published today as a Reviewed