DNA

Researchers have determined that type II innate lymphoid cells (ILC2s), a type of immune cell, can change its characteristics and functions after a cancer patient receives stem cells from a donor, thereby preventing an effective, healthy rebuilding of the immune system. This new understanding of ILC2 cells' transformational flexibility could lead to better strategies for

Researchers have developed a model that more accurately predicts how genetics and air pollution levels causally influence disease development. Every disease is shaped by a genetic component as well as environmental factors like air pollution, climate and socioeconomic status. However, the extent to which genetics or environment plays a role in disease risk -- and

Modern cutting-edge research generates enormous amounts of data, presenting scientists with the challenge of visualizing and analyzing it. Researchers have developed a tool for visualizing large data sets. The sCIRCLE tool allows users to explore single-cell analysis data in an interactive and user-friendly way. Modern cutting-edge research generates enormous amounts of data, presenting scientists with

Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: many patients, including those whose cancer goes into full remission, eventually relapse. Researchers report on a technique with the potential to eliminate that problem. Even as they have revolutionized the treatment of certain

Substituting amines with phosphonium-based cations could greatly improve the performance of mRNA-loaded polymeric micelles, report scientists. By adopting this innovative strategy, they managed to enhance the stability and mRNA-delivery capabilities of micelle nanocarriers into tumor tissue in vivo. Their results hint at the importance of exploring other cations besides amines in mRNA drug delivery and

New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Researchers found that intensifying the motion of molecules within the nanofibers led to more components needed for regeneration. After just four hours, the treatment activated the gene expression necessary to generate cartilage. Therapy could

In an important study for understanding how memories are made, cientists show that the flexibility of chromatin -- packaged DNA inside the cell -- plays a crucial role in 'deciding' which neurons are involved in forming a specific memory. When we form a new memory, the brain undergoes physical and functional changes known collectively as

Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome. The array represents a cost-effective, efficient method for exploring potential links between environmental exposures and epigenetic dysregulation during the early developmental origins of diseases and behavioral disorders. Researchers from

The researchers report the ability of protein 'signatures' to predict the onset of 67 diseases including multiple myeloma, non-Hodgkin lymphoma, motor neurone disease, pulmonary fibrosis, and dilated cardiomyopathy. Protein 'signatures', which can be obtained via a blood sample, can be used to predict the onset of 67 diseases including multiple myeloma, non-Hodgkin lymphoma, motor neurone

New research has found that specific genes may be related to the trajectory of recovery for stroke survivors, providing doctors insights useful for developing targeted therapies. New research led by UCLA Health has found that specific genes may be related to the trajectory of recovery for stroke survivors, providing doctors insights useful for developing targeted

New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what

New insights into the prevalence and mechanisms of gene misexpression in a healthy population could help in diagnosing and developing treatments for complex diseases. Scientists have uncovered that 'gene misbehaviour' -- where genes are active when they were expected to be switched off -- is a surprisingly common phenomenon in the healthy human population. The