Researchers have created a novel material that optimizes the use of enzymes. This development has enhanced the reaction efficiency and long-lasting stability of enzymes in electrochemical biosensors, which are crucial for health care and other purposes. Additionally, the researchers have significantly improved the performance of these devices.
Enzymes are essential for the chemical reactions that take place both in the human body and in nature. However, one of the major challenges in employing enzymes for electronic devices like sensors is facilitating effective and efficient electron transfer between the enzymes and electrodes, particularly with traditional technologies.
Recently, the research team tackled this issue by introducing a unique material known as metal-organic frameworks (MOFs). MOFs are crafted from metals and organic linkers, forming a porous crystalline structure, and they are frequently used in gas adsorption and separation, among other applications. Typically, MOFs have low electrical conductivity and are not involved in redox reactions; thus, the researchers revamped the MOF structure with materials that enhance electron conduction and promote specific redox reactions (these materials are termed redox mediators). The enhanced material functions like a “wire,” enabling effective electron transfer between the enzyme and the electrode. Moreover, the structure of the MOFs is designed to provide easy access to the enzyme’s hidden active sites. Another key aspect involved developing a suitable nanoscale structure and a practical strategy for immobilizing the enzyme on the electrode surface, which helps prevent the enzyme from leaching and ensures accurate measurements.
This innovative method makes it possible to achieve highly efficient and stable long-term readings from the enzyme-based biosensor. The team sees potential applications for this advancement in areas like disease diagnosis, environmental monitoring, and sustainable energy technologies. They believe that their work will not only further scientific knowledge but also enhance people’s lives.
