Alzheimer

Researchers have developed a way to study aged neurons in the lab without a brain biopsy, allowing them to accurately model the effects of aging in the development of late-onset Alzheimer's disease. By studying these cells, the researchers identified aspects of cells' genomes -- called retrotransposable elements, which change their activity as we age --

Neurotransmitter levels in the brain can indicate brain health and neurodegenerative diseases like Alzheimer's. However, the protective blood-brain barrier (BBB) makes delivering fluorescent sensors that can detect these small molecules to the brain difficult. Now, researchers demonstrate a way of packaging these sensors for easy passage across the BBB in mice, allowing for improved brain

A new study explored early-onset dementia in the working-age population in Finland. A new major study by the University of Eastern Finland, the University of Oulu and Neurocenter Finland explored early-onset dementia in the working-age population in Finland. The study cohort was one of the largest in the world to date, and the findings were

Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research. Mice don't get Alzheimer's -- and while that's good news for mice, it's a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The

Researchers offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer's Disease. Researchers at The Jackson Laboratory offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer's Disease in advance of

Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition. An MIT study published today in Nature provides new evidence for how specific cells and circuits become vulnerable in Alzheimer's disease, and hones in on other factors that may help some

Resulting atlas of the aging human brain holds molecular insights into the brain's vulnerability and resilience. Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to create an annotated library of all the gene readouts stored within 100 individual brain cells, the task felt daunting. Now, with technological advances, Mathys successfully

Oligodendrocytes are an important source of amyloid beta and play a key role in promoting neuronal dysfunction in Alzheimer's disease, according to a new study. Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer's disease (AD), according to a study published July 23, 2024

Decline in memory and other thinking abilities is the most well-known result of Alzheimer's disease (AD). However, many individuals with this condition also experience mental health symptoms such as agitation, depression, apathy, and trouble with sleep. A new study has found that the pathology behind AD may be a direct reason for emotional and behavioral

Scientists investigating Alzheimer's disease have determined the structure of molecules within a human brain. Their study describes how scientists used cryo-electron tomography, guided by fluorescence microscopy, to explore deep inside an Alzheimer's disease donor brain. This gave 3-dimensional maps in which they could observe proteins within the brain. Scientists investigating Alzheimer's disease have determined the

Scientists have developed an artificially-intelligent tool capable of predicting in four cases out of five whether people with early signs of dementia will remain stable or develop Alzheimer's disease. The team say this new approach could reduce the need for invasive and costly diagnostic tests while improving treatment outcomes early when interventions such as lifestyle

Researchers have unveiled a pioneering study shedding light on the intricate mechanisms underlying Alzheimer's disease (AD). Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have unveiled a pioneering study shedding light on the intricate mechanisms underlying Alzheimer's disease (AD). The study, titled "Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype," represents