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Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

Unlocking Precision Medicine: The Hidden Impact of Proteins on Existing Medications

Fewer side effects, improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level. Researchers have now succeeded in mapping the interactions of 144 active substances with around 8,000 proteins. The results could help

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Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

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Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

Revolutionizing Drug Screening: The Power of Electrical Impedance Tomography for Extracellular Voltage Activation

Recently, researchers developed a non-invasive method combining electrical impedance tomography and extracellular voltage activation to evaluate drug effects on ion channels. The resulting printed circuit board sensor allows real-time monitoring of how newly developed drugs can affect ion flow in channels, providing a cost-effective and accurate alternative to traditional methods like patch-clamp techniques and paving

Unlocking Precision Medicine: The Hidden Impact of Proteins on Existing Medications

Fewer side effects, improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level. Researchers have now succeeded in mapping the interactions of 144 active substances with around 8,000 proteins. The results could help
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Crafting Models: Understanding Belief Dynamics Through Engaging Analogies

Researchers who study belief dynamics often use analogies to understand and model the complex cognitive-social systems that underlie why we believe the things we do and how those beliefs can change over time. Ideas can be transmitted like a virus, for instance, 'infecting' a population as they spread from person to person. We might be

Enhancing the Design of mRNA-Loaded Nanocarriers for Precision Treatment Solutions

Substituting amines with phosphonium-based cations could greatly improve the performance of mRNA-loaded polymeric micelles, report scientists. By adopting this innovative strategy, they managed to enhance the stability and mRNA-delivery capabilities of micelle nanocarriers into tumor tissue in vivo. Their results hint at the importance of exploring other cations besides amines in mRNA drug delivery and

Threads of Design: The Art and Science Behind Ciliated Organ Morphology

Scientists present a new understanding of the connection between two distinct mechanisms for pumping fluids in living organisms: the 'flame' model and the 'carpet' model of ciliated ducts. The new findings enable greater clarity when studying and managing major pathologies that are associated with cilia malfunction and fluid buildup, including bronchiectasis, hydrocephalus and ectopic pregnancy.

Uncovering Connections: How a New Canine Disease is Providing Insights into Cystic Fibrosis

A canine gallbladder disease that involves the accumulation of abnormal mucus similar to that seen in human cystic fibrosis (CF) patients is caused by improper expression of the gene associated with CF in humans. The finding could have implications for human CF patients as well as for animal models of CF. A canine gallbladder disease

Maternal Flu’s Alarming Effects on Fetal Brain Development Revealed in Groundbreaking Mouse Study

New research using live mouse-adapted influenza virus improves upon previous mouse experiments to explain how maternal infection impacts fetal brain development. The study also indicates fetal brain changes are more likely once the severity of the mother's infection meets a specific threshold. A bad case of the flu during pregnancy can increase the risk for

Promising New Drug Candidate Overcomes Resistance to Cancer Treatments

A team of researchers has designed a molecule that impairs signaling mediated by two key drivers of cancer therapy resistance. A team of researchers at the University of Michigan Health Rogel Cancer Center has designed a molecule that impairs signaling mediated by two key drivers of cancer therapy resistance. The design and preclinical evaluation of

New Research Reveals Mental Health Care Deficiencies in Chronic Pain Management

A new study found that adults with chronic pain are more likely to experience symptoms of anxiety and depression than people without chronic pain, yet they access mental health care at lower rates and are less likely to have their mental health needs met in treatment. A new University of Arizona Health Sciences study found

Tracking Daily Patterns of Air Pollution Exposure

For people moving through the Bronx at different times, exposure to particulate matter 2.5 microns or bigger rises by about 2.4 percent when daily travel patterns are taken into account, according to a new study. There are significant differences in how much people are exposed to air pollution, according to a new study co-authored by

Groundbreaking Non-Invasive Method Captures Involuntary Nervous System Activity

A research team has shown that a wearable, non-invasive device can measure activity in human cervical nerves in clinical settings. The results could help medical professionals tailor treatments for inflammatory conditions like sepsis and PTSD. A research team led by UC San Diego has, for the first time, shown that a wearable, non-invasive device can

Discovering Disease Links: How Array Pinpoints Imprinted Genes Impact Health

Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome. The array represents a cost-effective, efficient method for exploring potential links between environmental exposures and epigenetic dysregulation during the early developmental origins of diseases and behavioral disorders. Researchers from

Enhancing Cancer-Killing Cells: How Electrical Currents Boost Immune Response

Scientists have discovered that electrical currents may make Natural Killer (NK) cells -- our very own cancer-killing immune cells -- even better killers, which could have significant implications for treating some cancers. The scientists found that Tumour Treating Fields (TTF) in the laboratory (which mimic exposure of brain tumors to electric currents via a simple

Discovering the Key Protein Behind Shingles Virus Spread: Insights from Scientists

Scientists have discovered a new evasion strategy used by the varicella zoster virus, which causes chickenpox and shingles, that may allow it to affect tissues far from the original site of infection. Scientists at the University of Colorado Anschutz Medical Campus have discovered a new evasion strategy used by the varicella zoster virus, which causes