Bone

A new study has found that people with newly diagnosed OA (knee or hip) with contraindications to or precautions for NSAIDs use continue to be prescribed these drugs. Additionally they had higher use of opioids and slightly lower physical therapy (PT) use within the first year of OA diagnosis, both of which are not consistent

New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Researchers found that intensifying the motion of molecules within the nanofibers led to more components needed for regeneration. After just four hours, the treatment activated the gene expression necessary to generate cartilage. Therapy could

Spinal muscular atrophy (SMA) is a severe neurological disease for which there is presently no cure, although current therapies can alleviate symptoms. In the search for better treatment options, scientists are now drawing attention to previously unnoticed abnormalities in embryonic development. They base their argument on studies of so-called organoids: Laboratory-grown tissue cultures that can

Surgeons compared traditional and new fully hydroxyapatite-coated hip replacement stems. They found the new stems offer larger contact areas, while traditional ones preserve bone density long-term. This insight aims to improve patient outcomes and reduce revision surgeries. Needing a hip replacement is unfortunate, but even more unfortunate is to need to do it again. Surgeons

The shape of a person's kneecap could be an indicator of whether they're more at risk of developing osteoarthritis, according to a new study. The shape of a person's kneecap could be an indicator of whether they're more at risk of developing osteoarthritis, according to a new study from The Australian National University (ANU). According

A simple blood test that measures the number of lymphocytes, a type of white blood cell in the body, may predict whether people who have relapsed multiple myeloma are going to respond well to CAR-T immunotherapy, according to new research. A simple blood test that measures the number of lymphocytes, a type of white blood

In a finding that opens the door to the development of targeted therapies for various muscle disorders, newly published research identifies key mechanisms of skeletal muscle regeneration and growth of muscles following resistance exercise. Newly published research from the University of Houston College of Pharmacy identifies key mechanisms of skeletal muscle regeneration and growth of

A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles. The research focuses on delivering a series of protein packets inside shuttle vectors to replace the defective DMD

Researchers propose an improvement in the identification of human remains using craniofacial superimposition. The forensic identification technique is based on the analysis of a skull (post-mortem) and photographs of the person's face (ante-mortem). It represents a major step in making objective decisions that are based on the ability to quantify the probability that a skull

Researchers have developed a novel deep learning algorithm that outperformed existing computer-based osteoporosis risk prediction methods, potentially leading to earlier diagnoses and better outcomes for patients with osteoporosis risk. Osteoporosis is so difficult to detect in early stage it's called the "silent disease." What if artificial intelligence could help predict a patient's chances of having

A medical team has developed a minimally invasive neurosurgical technique using an endoscope for the removal of tumors in the base of the skull. The results compare favorably with the conventional microscopic approach, with the added benefit of shorter operative times, less blood loss, and smaller craniotomies. Tumors arising in the base of the skull

Researchers have developed a python-tooth-inspired device as a supplement to current rotator cuff suture repair, and found that it nearly doubled repair strength. Their biomimetic approach following the design of python teeth helps to reattach tendons to bone more securely. The device not only augments the strength of the repair but can also be customized