DNA

Researchers conducted a breakthrough proof-of-concept study that found an HIV-like virus particle that could cease the need for lifelong medications. Researchers in George Mason University's Center for Infectious Disease Research (CIDR) and Tulane National Primate Research Center conducted a breakthrough proof-of-concept study in Nature's Gene Therapy that found an HIV-like virus particle that could cease

Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to

Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on

A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report. A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionise the response to future pandemics. Called FAIRY (Fluorescence Assay for vIRal IntegritY), the assay can screen

Scientists use a multimodal approach that combines hard X-ray computed tomography and X-ray fluorescence imaging to see the structure and chemical processes inside of a single cell. Every plant, animal, and person is a rich microcosm of tiny, specialized cells. These cells are worlds unto themselves, each with their own unique parts and processes that

New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance. A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago. For a new paper

A stroke not only causes acute damage to the brain, but can also have long-term health implications for other organs -- such as the heart. Researchers have worked on the hypothesis that the high rate of comorbidities that develop after a stroke could have a common immunological cause. And they actually managed to find it:

Scientists utilize logic gate-based decision-making to construct circuits that control genes. Guides typically assist tourists with directions, but the experience could be greatly enhanced if they offered personalized services tailored to individual interests. Recently, researchers have transformed guide RNAs, which direct enzymes, into a smart RNA capable of controlling networks in response to various signals.

A new study finds that early detection of specific microRNAs (miRNAs) packaged in vesicles may offer the opportunity to predict preeclampsia in pregnant people before clinical symptoms manifest. Preeclampsia (PE) is a significant contributor to the increase in maternal morbidity and mortality worldwide, with particularly alarming numbers in the United States, where it affects about

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study. The effectiveness of CAR T cell therapy against a variety of

The majority of rare diseases have a genetic cause. The underlying genetic alteration can be found more and more easily, for example by means of exome sequencing (ES), leading to a molecular genetic diagnosis. ES is an examination of all sections of our genetic material (DNA) that code for proteins. The majority of rare diseases

Scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes. USC scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody