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Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

Revolutionizing Skin Health: Unveiling the Secrets of Sebum Production Through a Molecular Lens

Changes in gene expression in sebaceous glands have now been spatially mapped. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production. In a collaborative project between the Faculty of Veterinary Medicine and the Interdisciplinary Centre for Bioinformatics (IZBI)

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Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

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Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

Unraveling the Genetic Similarities: Humans and Baker’s Yeast in DNA Replication

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the first time a molecular complex -- called CTF18-RFC in humans and Ctf18-RFC in yeast -- that loads a 'clamp' onto DNA to

Revolutionizing Skin Health: Unveiling the Secrets of Sebum Production Through a Molecular Lens

Changes in gene expression in sebaceous glands have now been spatially mapped. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production. In a collaborative project between the Faculty of Veterinary Medicine and the Interdisciplinary Centre for Bioinformatics (IZBI)
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Unveiling OTX2: The Unexpected Driver of Aggressive Medulloblastoma

Researchers revealed an unexpected way in which the protein OTX2 drives the progression of medulloblastoma -- the most common aggressive childhood brain cancer. The findings suggest that targeting OTX2 or its effects can have therapeutic relevance. In a report published in Nature Cell Biology, researchers at Baylor College of Medicine, Texas Children's Hospital, the University

Unlocking Chronic Pain Relief: How the Tell-Tale Gene Influences Drug Effectiveness

Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows. Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows. In

Genetic Study: Diversity’s Role in Health Disparities Revealed

Researchers conduct large-scale studies with diverse groups to better understand the genetic factors that influence health and disease. The Million Veteran Program (MVP), for example, includes people from various backgrounds along with their detailed health records. A new study analyzed genetic data from 635,969 veterans and 2,069 traits and identified a total of 26,049 associations

New Study Reveals Breakthrough in Addressing Genetic Diversity Bias

Scientists have generated a new catalog of human gene expression data from around the world to address how most research in human genetics has historically focused on people of European ancestries -- a bias that may limit the accuracy of scientific predictions for people from other populations. Most research in human genetics has historically focused

New Gene Therapy for Muscular Dystrophy: Promising Treatment Option

A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles. The research focuses on delivering a series of protein packets inside shuttle vectors to replace the defective DMD

Revolutionizing Epigenetics: CoRSIVs Discovered in Cattle, Not Just Humans

A study opens new possibilities to improve production efficiency in the cattle industry and potentially animal agriculture more broadly. A study published in Genome Biology opens new possibilities to improve production efficiency in the cattle industry and potentially animal agriculture more broadly. A team of researchers at Baylor College of Medicine, Cornell University and the

Uncovering the Key Driver for Epithelial Cancer Development: A Breakthrough Discovery

A distinct signaling pathway called TNF- drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF- program and become invasive. This finding could help to improve early detection and treatment of patients with cancers in skin, esophagus, bladder or colon. How does a normal cell in the

Genome recording makes living cells their own historians

Genomes can now be used to store information about a variety of transient biological events inside of living cells, as they happen, like a flight recorder collecting data from an aircraft. The method, called ENGRAM, aims to turn cells into their own historians. ENGRAM couples each kind of biological signal or event inside a cell

Genetic Cancer Risks Uncovered in 550 Patients: Study Reveals Crucial Insights

Current screening protocols fail to catch a notable number of people carrying genetic mutations associated with hereditary breast and ovarian cancer syndrome and Lynch syndrome, which increase the risk of developing certain cancers, according to new findings. Current screening protocols fail to catch a notable number of people carrying genetic mutations associated with hereditary breast

New Study: How Cell Donor’s Socioeconomic Status Impacts Cancer Treatment Outcomes

New research demonstrates that the socioeconomic status (SES) of cell donors affects the health outcomes of blood cancer patients who underwent hematopoietic cell transplantation (HCT). Published in PNAS, a research team led by the University of Minnesota Medical School demonstrated that the socioeconomic status (SES) of cell donors affects the health outcomes of blood cancer

Revolutionizing Infant Genetics Research: A Game-Changer for Lives

Investment in research into genetics could dramatically improve educational policies and understanding of parenting in ways that could help all children, according to a new paper. Investment in research into genetics could dramatically improve educational policies and understanding of parenting in ways that could help all children, according to a new paper led by the

CRISPR RNA Detection: Expanding the Gene Editing Toolkit

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy. CRISPR-Cas systems, defense systems