DNA

Researchers revealed an unexpected way in which the protein OTX2 drives the progression of medulloblastoma -- the most common aggressive childhood brain cancer. The findings suggest that targeting OTX2 or its effects can have therapeutic relevance. In a report published in Nature Cell Biology, researchers at Baylor College of Medicine, Texas Children's Hospital, the University

Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows. Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows. In

Researchers conduct large-scale studies with diverse groups to better understand the genetic factors that influence health and disease. The Million Veteran Program (MVP), for example, includes people from various backgrounds along with their detailed health records. A new study analyzed genetic data from 635,969 veterans and 2,069 traits and identified a total of 26,049 associations

A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles. The research focuses on delivering a series of protein packets inside shuttle vectors to replace the defective DMD

A study opens new possibilities to improve production efficiency in the cattle industry and potentially animal agriculture more broadly. A study published in Genome Biology opens new possibilities to improve production efficiency in the cattle industry and potentially animal agriculture more broadly. A team of researchers at Baylor College of Medicine, Cornell University and the

Scientists have generated a new catalog of human gene expression data from around the world to address how most research in human genetics has historically focused on people of European ancestries -- a bias that may limit the accuracy of scientific predictions for people from other populations. Most research in human genetics has historically focused

A distinct signaling pathway called TNF- drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF- program and become invasive. This finding could help to improve early detection and treatment of patients with cancers in skin, esophagus, bladder or colon. How does a normal cell in the

Genomes can now be used to store information about a variety of transient biological events inside of living cells, as they happen, like a flight recorder collecting data from an aircraft. The method, called ENGRAM, aims to turn cells into their own historians. ENGRAM couples each kind of biological signal or event inside a cell

Current screening protocols fail to catch a notable number of people carrying genetic mutations associated with hereditary breast and ovarian cancer syndrome and Lynch syndrome, which increase the risk of developing certain cancers, according to new findings. Current screening protocols fail to catch a notable number of people carrying genetic mutations associated with hereditary breast

New research demonstrates that the socioeconomic status (SES) of cell donors affects the health outcomes of blood cancer patients who underwent hematopoietic cell transplantation (HCT). Published in PNAS, a research team led by the University of Minnesota Medical School demonstrated that the socioeconomic status (SES) of cell donors affects the health outcomes of blood cancer

Investment in research into genetics could dramatically improve educational policies and understanding of parenting in ways that could help all children, according to a new paper. Investment in research into genetics could dramatically improve educational policies and understanding of parenting in ways that could help all children, according to a new paper led by the

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy. CRISPR-Cas systems, defense systems