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The study provides the basis for a phase I clinical trial in additional participants. Immune system dysregulation and elevated inflammation contribute to the development of the fatal neurodegenerative condition amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. In new research published in The FASEB Journal, repeated infusions of certain immune cells delayed ALS

A study found distinct signatures in CD8-positive T cells in blood samples from children with newly diagnosed type 1 diabetes and in autoantibody-positive children who later developed type 1 diabetes. A study conducted at the University of Eastern Finland found distinct signatures in CD8-positive T cells in blood samples from children with newly diagnosed type

Researchers have revealed a novel association between chromosome 18q deletion syndrome and late-onset combined immunodeficiency (LOCID). Their finding challenges the previously held notion that 18q deletion syndrome only involves humoral immunodeficiency affecting B cells and antibody production. Moreover, the study highlights the need for regular immune function testing in 18q deletion syndrome patients for early

International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of 'jumping genes.' DDM1 makes 'jumping genes' more accessible for transcription-suppressing chemical marks to be deposited. Because

Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design. Scientists at the University of Cambridge have developed an atlas of proteins describing how they behave inside human cells. This tool could be used to search for the origins of diseases which are related to proteins misbehaving such

When confronted with an antibiotic, toxic substance, or other source of considerable stress, bacteria are able to activate a defense mechanism using cell-to-cell communication to 'warn' unaffected bacteria, which can then anticipate, shield themselves and spread the warning signal. When confronted with an antibiotic, toxic substance, or other source of considerable stress, bacteria are able

Researchers restored hearing in preclinical mouse models with a specific form of inherited deafness called DFNA50 caused by mutations in microRNA, by using a novel in vivo CRISPR genome editing approach. Since mouse and human microRNAs have identical sequences, the researchers hope this work can one day be translated into applications for humans. A team

In preclinical studies, a team of researchers report new findings on a therapeutic combination that regenerated human insulin-producing beta cells, providing a possible new treatment for diabetes. In preclinical studies, a team of researchers from Mount Sinai Health System in New York City and City of Hope in Los Angeles report new findings on a

Cystic fibrosis is one of the most common genetic disorders, causing thick mucus build-up in the lungs and other parts of the body, breathing problems, and infection. Now, researchers have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. With further development, it

An unexpected find has enabled important progress to be made in the battle against harmful bacteria. An unexpected find has enabled important progress to be made in the battle against harmful bacteria. An international team of researchers, led by Professor Peter Fineran from the University of Otago, investigated a particular protein used by bacteria-infecting viruses

New research shows how stem cell-derived therapy, targeting treatment-resistant liver cancer through genetically modified NK cells, offers promising new avenues for immunotherapy. Researchers at University of California San Diego have found that the most common form of liver cancer -- one with a high mortality rate -- can be better targeted and treated using an

Researchers have provided new insights into the lasting effects of chronic Hepatitis C virus (HCV) infection on the immune system, even after the disease has been successfully treated. The research team has discovered that traces of 'epigenetic scars' remain in regulatory T cells and exhibit sustained inflammatory properties long after the virus is cleared from