Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can
Changes in gene expression in sebaceous glands have now been spatially mapped. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production. In a collaborative project between the Faculty of Veterinary Medicine and the Interdisciplinary Centre for Bioinformatics (IZBI)
Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can
Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can
Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the first time a molecular complex -- called CTF18-RFC in humans and Ctf18-RFC in yeast -- that loads a 'clamp' onto DNA to
Changes in gene expression in sebaceous glands have now been spatially mapped. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production. In a collaborative project between the Faculty of Veterinary Medicine and the Interdisciplinary Centre for Bioinformatics (IZBI)
Flies has uncovered groundbreaking evidence that oocytes undergo regular rejuvenation of protein linkages that bind chromosomes together, potentially reducing the risk of pregnancy complications in aging women. This pivotal discovery has the potential to revolutionize our understanding of reproductive health and offer new hope for women seeking to conceive later in life
To innovative treatment options for metastatic cancer, particularly benefiting pancreatic cancer patients. Gstt1 expression plays a pivotal role in transforming the cellular environment to promote growth, offering potential for groundbreaking therapies in cancer treatment
Health. This breakthrough in genetic research has the potential to revolutionize how CAD is diagnosed and treated, offering hope for improved patient outcomes and a deeper understanding of the disease at a molecular level. With these rare coding variants now identified, the door is open to developing precision medicine strategies tailored to individual patients, ultimately leading to more effective and personalized treatment options for those at risk of CAD
Carried unique CARD9 variants. This discovery sheds light on the diversity of these mutations and emphasizes the importance of studying different populations to understand genetic predispositions to fungal infections. By uncovering the specific variants present in East Asian populations, this research has significant implications for personalized medicine and targeted treatments for fungal-related diseases. The study's findings provide valuable insights into the genetic diversity of CARD9 variants and their impact on susceptibility to severe fungal infections, paving the way for more tailored and effective healthcare strategies
RNA into its own genome, allowing it to evade the immune system and resist treatment. This groundbreaking discovery sheds light on the mechanisms behind chronic Hepatitis E and paves the way for the development of more effective therapies. The study's findings have far-reaching implications for the understanding and management of Hepatitis E and other viral infections
Kind genetic mutations. This innovation represents a significant step forward in the field of genetic engineering and holds great promise for the future of medical treatment
Found a possible link between Bartonella DNA and psychotic disorders, suggesting that vector-borne pathogens may play a role in mental illness. This research sheds light on an important and previously overlooked aspect of mental health, potentially opening up new avenues for treatment and understanding
The treatment of melanoma resistant to targeted therapies. They have found that inhibition of the VARS enzyme could prevent therapeutic resistance by resensitizing tumors. This groundbreaking discovery offers a potential new avenue for treating this aggressive form of cancer, with the potential to significantly impact patient outcomes
Offers a unique approach to controlling and delivering RNA, with the ability to reverse the process as needed. By using disulfide-containing small molecules, this strategy showcases unprecedented versatility and precision in the field of RNA manipulation. The innovative combination of post-synthetic RNA acylation chemistry and dynamic disulfide exchange reaction sets this method apart, promising to revolutionize the way RNA is controlled and delivered in the future
Are active in any given cell at a particular time. With this new method, scientists can now track gene and enhancer activity simultaneously, giving them a more comprehensive understanding of how genes are regulated. This breakthrough has the potential to revolutionize the field of genetic research and lead to the development of more targeted and effective treatments for a wide range of genetic diseases
Older adults. These findings could revolutionize our understanding of the condition and pave the way for more effective treatments. With this new knowledge, individuals at higher risk of developing restless leg syndrome can be identified and targeted for early intervention. This breakthrough offers hope for those suffering from the discomfort and sleep disturbances associated with restless leg syndrome