DNA

A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells. Genome editing has become a widely adopted technology to modify

Researchers have identified a small molecule that could lead to a safe and effective treatment for the neurodevelopmental condition known as Angelman syndrome. Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities. Though there isn't a cure

Researchers have mapped all the possible outcomes of changes to a tumor-suppressing gene called VHL, the first step in a huge research endeavor to unpick the outcomes of tens of thousands of genetic variations in genes associated with cancer. Researchers at the Francis Crick Institute have mapped all the possible outcomes of changes to a

Researchers have found a way to reprogram disease evolution and design tumors that are easier to treat. They created a modular genetic circuit that turns cancer cells into a 'Trojan horse,' causing them to self-destruct and kill nearby drug-resistant cancer cells -- a novel way to address cancer's inherent diversity and heterogeneity. Treating cancer can

Researchers have developed a discovery platform to probe the function of genes involved in metabolism -- the sum of all life-sustaining chemical reactions. The investigators used the new platform, called GeneMAP (Gene-Metabolite Association Prediction), to identify a gene necessary for mitochondrial choline transport. A multidisciplinary research team has developed a discovery platform to probe the

Researchers have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma. The discoveries were made possible by a newly developed technology they call ReapTEC. The new T cell atlas is publicly available and should help in the development of new drug

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice. An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen.

Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a 'one-size-fits-all' remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings publishing July 2 in Nature Medicine. Drugs that selectively kill senescent cells may benefit otherwise

In a recent study, researchers suggest the cell's messenger RNA (mRNA) -- the major translator and regulator of genetic material -- along with a critical protein called ZAK, spur the cell's initial response to UV radiation damage and play a critical role in whether the cell lives or dies. In a recent study, researchers at

Scientists have identified a gene which, when missing or impaired, can cause obesity, behavioural problems and, in mothers, postnatal depression. The discovery, reported today in Cell, may have wider implications for the treatment of postnatal depression, with a study in mice suggesting that oxytocin may alleviate symptoms. Scientists have identified a gene which, when missing

A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more efficiently. A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more

A new study in mice hints at the promise of an eventual alternative treatment option for the 'wet' version of age-related macular degeneration (AMD). Researchers determined in mice that an enzyme related to cell growth and division is a culprit in the blood vessel invasion in the back of the eye that causes blurred central