DNA

Researchers show for the first time that engineered human plasma B cells can be used to treat a disease -- specifically leukemia -- in a humanized animal model. The results mark a key step in the realization of ePCs as therapies to treat cancer, auto-immune disorders, and protein deficiency disorders. Researchers show for the first

A study provides new clues in the understanding of how antibiotic resistance spreads. The study shows how an enzyme breaks down the bacteria's protective outer layer, the cell wall, and thus facilitates the transfer of genes for resistance to antibiotics. A study at Umeå University, Sweden, provides new clues in the understanding of how antibiotic

Multiple myeloma is one of the most common forms of cancer of the immune cells in the bone marrow. It is considered incurable. Even when patients respond to treatment at first, the cancer comes back. To be able to intervene faster and on a more targeted basis, researchers completed a comprehensive study of this disease

Genes can indirectly influence the age at which girls have their first period by accelerating weight gain in childhood, a known risk factor for early puberty. Other genes can directly affect age of puberty, some with profound effects. Genes can indirectly influence the age at which girls have their first period by accelerating weight gain

An innovative combination of methods to identify and study how macrophages function could potentially revolutionize the diagnosis and treatment of various diseases. Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair. Understanding how these cells are activated in different scenarios is important for developing new medical treatments.

Researchers have reported finding major differences between postmortem and living prefrontal cortex brain tissues as they relate to one of the most abundant RNA modifications in the brain, known as adenosine-to-inosine (A-to-I) editing. Researchers from the Icahn School of Medicine at Mount Sinai have shed valuable light on the nuanced functions and intricate regulatory methods

A new study has demonstrated the potential of stem cell therapy to treat those with Hirschsprung disease. A new study led by researchers at UCL and the University of Sheffield, has demonstrated the potential of stem cell therapy to treat those with Hirschsprung disease. Hirschsprung disease is a rare condition where some nerve cells are

Researchers found that men with a higher proportion of blood cells missing Y chromosomes have a higher mortality rate from a common cause of heart disease called transthyretin cardiac amyloidosis (ATTR-CA), informing future treatment for patients with ATTR-CA. Researchers at Boston Medical Center (BMC) and Boston University (BU) Chobanian & Avedisian School of Medicine, in

Researchers have harnessed a bacterial immune defense system, known as CRISPR, to efficiently and precisely control the process of RNA splicing. The technology opens the door to new applications, including systematically interrogating the functions of parts of genes and correcting splicing deficiencies that underlie numerous diseases and disorders. Researchers at the University of Toronto have

Researchers have uncovered how specific DNA rearrangements called inverted triplications contribute to the development of various genetic diseases. The study reveals that during DNA repair, segments may switch templates within inverted repeats, leading to structural variations and gene dosage alterations, impacting conditions like MECP2 duplication syndrome. This discovery opens new avenues for understanding and treating

Lymphoblastic Leukemia T cells appear hundreds of years old. This study sheds light on the aging process of T cells and the potential implications for leukemia treatment. It showcases the innovative use of epigenetic analysis and mouse models to uncover groundbreaking insights into cellular aging and disease progression. This research has the potential to revolutionize our understanding of T cell biology and open new avenues for targeted therapies in leukemia treatment

As well as in other age-related diseases in women. Understanding these genetic variants could lead to improved screening and early detection of mLOX and other associated health issues. This could potentially revolutionize the way we approach women's health as they age, leading to more personalized and effective treatment strategies