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The Fitness Factor: Why Weight Isn’t the Whole Story

As rates of obesity, as defined by body mass index (BMI), continue to climb in the United States, so have efforts to lose weight, including a new era of weight-loss drugs. Yet a new systematic review and meta-analysis found that cardiorespiratory fitness was a stronger predictor of both cardiovascular disease and all-cause mortality than BMI.

A Breakthrough Finger Prick Test Could Revolutionize Alzheimer’s Diagnosis

A quick finger prick and a few drops of blood on a card that can be sent in regular mail. This approach could soon make Alzheimer's testing much more accessible worldwide. A quick finger prick and a few drops of blood on a card that can be sent in regular mail. This approach could soon

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The Fitness Factor: Why Weight Isn’t the Whole Story

As rates of obesity, as defined by body mass index (BMI), continue to climb in the United States, so have efforts to lose weight, including a new era of weight-loss drugs. Yet a new systematic review and meta-analysis found that cardiorespiratory fitness was a stronger predictor of both cardiovascular disease and all-cause mortality than BMI.

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The Fitness Factor: Why Weight Isn’t the Whole Story

As rates of obesity, as defined by body mass index (BMI), continue to climb in the United States, so have efforts to lose weight, including a new era of weight-loss drugs. Yet a new systematic review and meta-analysis found that cardiorespiratory fitness was a stronger predictor of both cardiovascular disease and all-cause mortality than BMI.

Beyond Cholesterol: The Hidden Lipid Contributors to Trans Fat-Induced Heart Disease

Salk scientists have tracked the flow of trans fats using mouse models to describe the molecular mechanisms that cause trans fats to promote atherosclerotic cardiovascular disease (ASCVD), explaining how industrially produced trans-unsaturated fatty acids in our food significantly promote ASCVD and encouraging lawmakers to impose regulations on the use of these fats in food. This

A Breakthrough Finger Prick Test Could Revolutionize Alzheimer’s Diagnosis

A quick finger prick and a few drops of blood on a card that can be sent in regular mail. This approach could soon make Alzheimer's testing much more accessible worldwide. A quick finger prick and a few drops of blood on a card that can be sent in regular mail. This approach could soon
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The Universal Language of Pain: Exploring How Cultures Express Suffering

An interdisciplinary team explored possible regularities in vocal emotional expressions by comparing expressive interjections, such as 'wow,' to nonlinguistic vocalizations, such as screams and cries, from across the globe. The researchers analyzed vowels in interjections from 131 languages, comparing them with nearly 500 vowels from vocalizations produced in joyful, painful, or disgusting contexts. Each of

Understanding Visual Impairment in Children: The Role of Brain Function

Experts have identified five elements of a brain-based condition that has emerged as a leading cause of vision impairment starting in childhood in the United States and other industrialized nations. Known as cerebral (or cortical) visual impairment (CVI), some estimates suggest that at least 3% of primary school children exhibit CVI-related visual problems, which vary

Heart Medications Might Lower Dementia Risk

Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study. Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study from Karolinska Institutet published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Cardiovascular disease and

Unveiling the Potential of an African Plant in HIV Latency Reversal

The Wistar Institute and the University of Buea in Cameroon has uncovered the mechanisms for a medicinal plant with anti-HIV potential in Croton oligandrus Pierre & Hutch, a species of African tree that has been used in traditional healing in Cameroon to treat a variety of diseases and conditions including cancers and diabetes. A collaboration

The Importance of L-Lysine: Understanding Its Essential Role in Our Health

L-Lysine is an essential amino acid. Here's why it matters. While research shows that the global dietary supplements' market was already exploding back in 2021 when it was valued at more than $152 billion, the industry is showing no signs of slowing down. In fact, one report shows that the global market will reach a staggering $300 billion by

Unveiling the Diverse Fibroblast Subtypes in Skin Cancer Research

A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment. The results are relevant for the development of novel skin cancer therapies, particularly in the field of immunotherapy. A study at MedUni Vienna's Department of Dermatology provides insights into

Redefining Cerebral Palsy: A New Perspective on Understanding and Care

Defining cerebral palsy only as a childhood condition fails to acknowledge the many adults living with the disease. In the United States, there are currently more adults living with cerebral palsy than children. Despite this, the Centers for Disease Control and Prevention still label cerebral palsy as "the most common motor disability in childhood." This

“Mastering Mouse Cells: Scientists Enhance Tissue Engineering Through Crowd Control Techniques”

Genes aren't the sole driver instructing cells to build multicellular structures, tissues, and organs. Biologists have now characterized the influence of another important developmental driver: cell density, or how loosely or tightly cells are packed into a given space. In both computational models and laboratory experiments, the team of scientists used cell density as an

Unlocking the Brain’s Mechanism for Calming Anxious Breathing

Scientists discovered a brain circuit that allows us to regulate voluntary breathing, which connects the brain's emotional and behavioral cortical area to its automatic breathing brainstem area. The findings provide a targetable area for slowing breathing in people with anxiety, panic disorders, or PTSD, in addition to explaining the efficacy of slowed, intentional breathing in

Harnessing Biophysics to Create Innovative Vaccines for RSV and Other Respiratory Viruses

In most people, the lung-infecting pathogens known as respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) trigger mild cold-like symptoms. But in infants and seniors, these viruses can cause severe pneumonia and even death. Vaccines against both viruses, however, have been difficult to design. Now, scientists have analyzed the structure and stability of a critical

Nurturing Minds: How Creativity Camps Boost Adolescent Mental Health and Happiness

A research team found that Creativity Camp, a two-week arts intervention delivered as a day camp, had a positive impact on mental health and well-being in adolescents with depression. Published in Child Psychiatry and Human Development, a research team led by the University of Minnesota Medical School found that Creativity Camp, a two-week arts intervention

Emerging Subtypes of a Widespread Brain Disorder

Researchers have used AI tools to describe three sub-types of Chiari type-1, which will help guide clinicians to make the most effective treatment decisions for their patients. Chiari type-1 malformation is a condition in which the cerebellum extends beyond the gap in the skull where it connects to the spinal cord. Roughly 4% of the