Health

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. The

There may be a link between hearing impairment and an increased risk of developing Parkinson's according to new research. This is one of the first studies to examine whether sensory impairments, such as hearing loss, might increase the risk for Parkinson's or serve as an early warning sign. Parkinson's UK reports that an estimated 153,000

Scientists have developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more. By knocking out a gene circuit responsible for producing lactic acid -- a metabolite that makes the cells' environment toxic -- researchers eliminate

Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting therapeutics with minimal side effects. Researchers have previously demonstrated antidepressant-like effects of delta opioid receptor agonists in rodents. In their latest study, they uncover the

A team of researchers has developed a new biomaterial with high potential in in the treatment of bone lesions or minimal residual disease in multiple myeloma patients. The findings showcase a promising approach to bone healing and tumor control. The team tackled a critical challenge in treating multiple myeloma -- a blood cancer where malignant

The new models could give antibiotics a laser-like precision to target only specific bacteria in specific parts of the body. This would represent a major step forward in the battle against the growing problem of antibiotic resistance. With antibiotic resistance a growing problem, University of Virginia School of Medicine researchers have developed cutting-edge computer models

Researchers have developed an artificial intelligence (AI) model to detect the spread of metastatic brain cancer using MRI scans, offering insights into patients' cancer without aggressive surgery. Researchers have developed an artificial intelligence (AI) model to detect the spread of metastatic brain cancer using MRI scans, offering insights into patients' cancer without aggressive surgery. The

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these structures have some important roles to play in a cell, R-loops in the wrong

Age-related macular degeneration (AMD), which affects about 200 million people worldwide and can result in legal blindness, impairs an area of the eye (retina) used for reading, driving and many other critical daily tasks. A new study of large existing patient datasets indicates genetic and demographic factors that increase the risk for developing AMD. Age-related

Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes. Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and young adults between the ages of 10 and 20, during times of rapid bone growth. Although rare, it has a significant impact on young people and

Wildfires that burn homes and vehicles could expose people to dangerous airborne compounds through ash and smoke. Research has shown that people returning to their unburned homes may also experience health symptoms months after a nearby fire is extinguished. Through a survey of people affected by the 2021 Marshall Fire in Boulder, Colorado, researchers found

A recent study provides new insights into the mechanisms of coagulation in persons with haemophilia A, the most common form of haemophilia. The research team was able to show that saliva contains special vesicles that trigger rapid coagulation of the blood of haemophilic patients. A recent study led by MedUni Vienna provides new insights into