from frozen embryos may have a higher risk of metabolic problems, while others have not found any significant differences between frozen and fresh embryo transfers. In this new study, the researchers sought to investigate this issue further by comparing the metabolic profiles of children born from frozen and fresh embryo transfers.
The study included 105 singleton children born through frozen embryo transfer and 287 born through fresh embryo transfer. The researchers analyzed the children’s metabolic profiles using a technique called gas chromatography-mass spectrometry, which can measure a wide range of small molecules in the blood.
the researchers found that the metabolic profiles of children born through frozen and fresh embryo transfers were similar. This suggests that the long-term metabolic health impacts of these two types of assisted reproductive technology may not be significantly different. However, the researchers note that further studies with larger sample sizes are needed to confirm these findings.
Frozen embryo transfer may pose a greater risk of metabolic disorders like obesity and unfavorable lipid profiles. However, some studies have found no significant metabolic differences between those born via frozen or fresh embryo transfer. In a recent study, researchers compared the glucose and lipid profiles of over 4,000 children ages 2 to 5, with about half born via fresh embryo transfer and the other half born via frozen embryo transfer. The children were monitored for an average of 3.6 years, and metabolic factors linked to heart disease and diabetes were assessed.
sting blood glucose, insulin, cholesterol, and triglycerides.
Researchers discovered that there were no variations in any of the metabolic factors between children who were born through fresh embryo transfer and those born through frozen embryo transfer.
Due to the large number of participants in the study, the researchers were able to conduct subgroup analyses. Even after categorizing the children into groups based on gender, age, embryo transfer state, and method of conception, there were still no differences in metabolic factors between the frozen and fresh embryo transfer groups.
This study offers valuable information to women and couples who are considering the advantages and disadvantages of different methods of conception.
There are a variety of methods available for assisted reproduction, but the researchers emphasized the necessity of more information regarding the impact of assisted reproductive technology on long-term metabolic health. The authors also mentioned, “Frozen embryo transfer does not appear to have any major negative effects on metabolic profiles in early childhood, which is important evidence for guiding couples undergoing assisted reproductive technology treatment on its safety.”
