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HomeHealthUncovering the Mechanism Fueling Aggressive B-Cell Lymphoma Growth: A Breakthrough Study

Uncovering the Mechanism Fueling Aggressive B-Cell Lymphoma Growth: A Breakthrough Study

Researchers from the University of Helsinki and HUS ​looked into how mutations in the KLHL6 gene‍ affect diffuse large B-cell lymphoma, which is the most common type of lymphatic system cancer.

The KLHL6 protein is responsible for getting rid of extra and unneeded proteins within the​ cells. When ⁣this system is disrupted in many cancers, it promotes the growth of malignant ​cells.

The⁤ researchers discovered ‌that the KLHL6 protein breaks down and disrupts the normal ‌process ⁢of getting‌ rid of unwanted proteins, leading to increased growth of ‍the most ⁢common type of lymphoma.The B-cell receptor was studied and⁣ found ⁣that specific mutations can cause an increase in the number of these receptors.

According to Doctoral Researcher Leo Meriranta, MD, from the University of‌ Helsinki, the B-cell receptor is an antibody located on the surface ⁣of⁣ B-lymphocytes. It is used by normal cells to ‌detect and fight pathogens. However, in abnormal cells, the B-cell ‌receptor becomes activated⁣ in a way that leads ​to tissue growth and the development of lymphoma.

Predicting poor treatment outcomes

During the study, it ‍was ⁢discovered that the absence of ⁣the KLHL6 protein in some ‌cancer patients could indicate poor treatment outcomes.Absolutely missing from cells.‌ Experimentation in the lab⁣ demonstrated that the absence of KLHL6 in lymphoma cells significantly ‍increased the number of B-cell receptors.

Sirpa ​Leppä, an Oncology Professor who leads the research group, emphasizes⁤ the clinical importance of KLHL6.

“Lymphoma cases ‍in ⁢which the KLHL6 protein was missing had a poor prognosis.⁣ Identifying ⁣pathogenic mechanisms ​relevant to these patients is crucial for improving ​their prognoses through drug development,” Leppä explains.

Therapy customization’s growing significance

A BritThe University‌ of Helsinki and HUS researchers, along with an ‍Irish-American research group, both found similar results. This suggests that disrupting the KLHL6 protein may be ⁢significant in certain B-cell diseases. Meriranta, a researcher, believes‍ that targeting therapies based ⁢on cancer biomarkers could improve ⁣treatment outcomes in the future. This‌ new discovery could lead to more tailored therapies,‌ as the abnormal amount ⁢and activity of the B-cell receptor‍ can potentially be targeted with medication. However, further research⁢ is still necessary.

Ranta notes.

Diffuse large B-cell lymphoma

  • Approximately 700 individuals in Finland are diagnosed with diffuse⁢ large B-cell lymphoma every year.
  • The primary symptom is ⁢the ​enlargement of lymph‌ nodes.
  • Treatment for the disease⁤ involves immunochemotherapy, which is⁢ a combination of antibodies and‌ cytostatic drugs.
  • In about 33% of cases,⁢ the⁢ cancer is⁣ not successfully cured and can be fatal.