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First-Ever Discovery of a Human Odorant Receptor for Geosmin Unveiled

Geosmin is a volatile compound of microbial origin with a distinct 'earthy' to 'musty' odor that can affect the quality of water and food. A research team has now identified and characterized the human odorant receptor for geosmin for the first time. Geosmin is a volatile compound of microbial origin with a distinct "earthy" to

Revolutionizing Drug Screening: The Power of Electrical Impedance Tomography for Extracellular Voltage Activation

Recently, researchers developed a non-invasive method combining electrical impedance tomography and extracellular voltage activation to evaluate drug effects on ion channels. The resulting printed circuit board sensor allows real-time monitoring of how newly developed drugs can affect ion flow in channels, providing a cost-effective and accurate alternative to traditional methods like patch-clamp techniques and paving

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First-Ever Discovery of a Human Odorant Receptor for Geosmin Unveiled

Geosmin is a volatile compound of microbial origin with a distinct 'earthy' to 'musty' odor that can affect the quality of water and food. A research team has now identified and characterized the human odorant receptor for geosmin for the first time. Geosmin is a volatile compound of microbial origin with a distinct "earthy" to

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First-Ever Discovery of a Human Odorant Receptor for Geosmin Unveiled

Geosmin is a volatile compound of microbial origin with a distinct 'earthy' to 'musty' odor that can affect the quality of water and food. A research team has now identified and characterized the human odorant receptor for geosmin for the first time. Geosmin is a volatile compound of microbial origin with a distinct "earthy" to

Revolutionary Nanosensing Method Enhances Quality Control of Viral Vectors in Gene Therapy

Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can

Revolutionizing Drug Screening: The Power of Electrical Impedance Tomography for Extracellular Voltage Activation

Recently, researchers developed a non-invasive method combining electrical impedance tomography and extracellular voltage activation to evaluate drug effects on ion channels. The resulting printed circuit board sensor allows real-time monitoring of how newly developed drugs can affect ion flow in channels, providing a cost-effective and accurate alternative to traditional methods like patch-clamp techniques and paving
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Preexisting Drug Resistance Uncovered: New Study Reveals Cancer Evolution

The evolution of resistance to diseases, from infectious illnesses to cancers, poses a formidable challenge. Despite the expectation that resistance-conferring mutations would dwindle in the absence of treatment due to a reduced growth rate, preexisting resistance is pervasive across diseases that evolve -- like cancer and pathogens -- defying conventional wisdom. The evolution of resistance

Immune System 101: Understanding the Basics and Boosting Your Defenses

Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the immune system. For analysis of the necessary complex antigen processing and transport processes in real time, researchers have developed a 'cage' that is opened with

Unveiling the Truth: Understanding the Differences in Stem Cell Therapies

Researchers have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of

Unlocking the Power of Immune Cells: The Importance of Spatial Arrangement in Tumor Defense

In order for immune cells to effectively kill cancer cells, a triad of three cells are necessary -- a dendritic cell, a cytotoxic 'killer' T cell, and a helper T cell, researchers have found. The discovery could alter the way doctors administer immunotherapies. There's a frustrating fact about today's immunotherapies for cancer. While sometimes they

Revolutionary Medical Imaging: Lab Creates Smallest Free-Floating Bubbles

Bioengineering researchers developed ultrasmall, stable gas-filled protein nanostructures that could revolutionize ultrasound imaging and drug delivery for cancers and infectious diseases. Bioengineering researchers at Rice University have developed ultrasmall, stable gas-filled protein nanostructures that could revolutionize ultrasound imaging and drug delivery. Unlike current microbubbles or nanobubbles that are too large to cross biological barriers effectively

Blood Fat Profiles: Health Benefits of Replacing Butter with High-Quality Plant Oils

Switching from a diet high in saturated animal fats to one rich in plant-based unsaturated fats affects the fat composition in the blood, which in turn influences long-term disease risk. A study shows that it is possible to accurately measure diet-related fat changes in the blood and directly link them to the risk of developing

New Study Reveals Alarming Cancer Statistics: 40% of Cases and Nearly Half of Deaths Linked to Modifiable Risk Factors

A new study finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States (or 713,340 cancer cases and 262,120 cancer deaths in 2019) could be attributed to modifiable risk factors, including cigarette smoking, excess body weight, alcohol consumption, physical inactivity, diet

Unlocking Africa’s Genetic Legacy: Advancing DNA and Ancient DNA Research

The American Journal of Human Genetics recently published a perspective piece on the need for an equitable and inclusive future for DNA and ancient DNA (aDNA) research in Africa. The paper highlights the fact that, while DNA from ancient and living African peoples is increasingly critical to the study of human evolution, African scientists remain

Derivative Synthesis Method for New Antimicrobial Drugs: A Comprehensive Approach

A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria. A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria. Efforts to combat the increasing threat of drug-resistant bacteria are being assisted by

The Geneticists’ Perspective: Rewriting the History of Neanderthals

Using genomes from 2,000 living humans as well as three Neanderthals and one Denisovan, an international team mapped the gene flow between the hominin groups over the past quarter-million years. Ever since the first Neanderthal bones were discovered in 1856, people have wondered about these ancient hominins. How are they different from us? How much

Malnutrition in Healthcare Facilities: The Overlooked Crisis and its Risks | Essential Nutrients for Patient Care

As many as half of all patients admitted to hospital and other healthcare facilities are malnourished. This has serious consequences for the individual in terms of unnecessary suffering, poorer quality of life and mortality. Providing nutrients can alleviate these problems, but not enough attention is paid to this knowledge, according to researchers in a new

Revolutionary Phage Access: Researchers Make Lifesaving Treatment More Portable and User-Friendly

Researchers have developed a simple way to bring bacteriophage therapy into much closer reach for clinicians struggling to save patients with antimicrobial-resistant infections. The technology makes it possible to sort through hundreds or even thousands of phages in less than two hours to identify which will respond to a particular infection. The great promise of