Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can
Changes in gene expression in sebaceous glands have now been spatially mapped. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production. In a collaborative project between the Faculty of Veterinary Medicine and the Interdisciplinary Centre for Bioinformatics (IZBI)
Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can
Researchers develop a nanosensing platform that can assess the quality of individual viral vector particles Viral vectors hold much potential for gene editing and gene therapy, but there is a pressing need to develop quality control methods to minimize potential side effects on patients. Addressing this, researchers from Japan developed a nanosensing-based approach that can
Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the first time a molecular complex -- called CTF18-RFC in humans and Ctf18-RFC in yeast -- that loads a 'clamp' onto DNA to
Changes in gene expression in sebaceous glands have now been spatially mapped. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production. In a collaborative project between the Faculty of Veterinary Medicine and the Interdisciplinary Centre for Bioinformatics (IZBI)
Aggregation of these proteins. This breakthrough offers hope for developing new treatments to slow or halt the progression of these devastating diseases. By understanding the pivotal role of tau in neurodegenerative diseases and finding ways to intervene, researchers are advancing towards innovative therapeutic strategies that could make a significant difference in the lives of patients and their families. The potential to disrupt the disease process at a foundational level makes this research a game-changer in the fight against FTD, PSP, CBD, and other related disorders
Short lengths of DNA repeated multiple times, known as tandem repeats, which are linked to over 50 lethal human diseases. This breakthrough will greatly aid in the understanding and diagnosis of diseases such as amyotrophic lateral sclerosis and Huntington's disease, as well as multiple cancers. The research team's work is a pivotal advancement in the field of genetics, offering a crucial tool for identifying and studying genetic factors in disease
New understanding of genetic variations that could potentially protect individuals from alcohol abuse and its related health issues. Using data from 23andMe, they have identified specific genetic variants that not only reduce the risk of alcohol dependency but also have implications for other health conditions and behaviors. This groundbreaking research offers insights into the complex interplay between genetics and substance abuse, ultimately paving the way for more targeted and personalized interventions for at-risk individuals. The study sheds light on the multifaceted impact of genetic factors on alcohol abuse and opens up new avenues for future research and preventative measures
Of how these long-lasting RNA molecules contribute to overall brain function and aging. This groundbreaking discovery could potentially lead to new insights into age-related neurological diseases and pave the way for future treatments. The implications of this research are significant, as it sheds light on the intricate mechanisms behind brain aging and opens up new possibilities for therapeutic interventions
Known as argininosuccinic aciduria, is a rare genetic disorder that affects the liver's ability to process ammonia, leading to a buildup of toxins in the body. This groundbreaking study offers hope for those suffering from this debilitating condition by providing a potential gene therapy solution. The team's success in correcting the gene defect marks a significant advancement in the field of genetic medicine and paves the way for potential treatments for other genetic liver diseases. This innovative research showcases the power of gene therapy in addressing complex genetic disorders and represents a promising step forward in the quest for effective treatments for ASLD
