Health

Researchers have described the neurodegeneration that occurs in the nervous system of the bowel in Batten disease, a rare and fatal genetic condition. In their latest study, a team showed that gene therapy to the bowel in mice modeling Batten disease reduced symptoms and extended lifespan. ssor of pediatrics, of genetics and of neurology at

Researchers have designed process that uses ultrasound to modify the behavior of cancer-fighting T cells by increasing their cell permeability. They targeted freshly isolated human immune cells with tightly focused ultrasound beams and clinically approved contrast agent microbubbles. When hit with the ultrasound, the bubbles vibrate at extremely high frequency, acting as a push-pull on

A new twist on a decades-old anticancer strategy has shown powerful effects against multiple cancer types in a preclinical study. The experimental approach, which uses tiny capsules called small extracellular vesicles (sEVs), could offer an innovative new type of immunotherapy treatment and is poised to move toward more advanced development and testing. A new twist

Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid aortic valve disease. Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid

Past studies have identified a loneliness-rumination-depression nexus. Rumination is defined as repetitive and intrusive negative thoughts and feelings, and loneliness as a gap between desired and actual social connections. Given a widely reported high co-occurrence between loneliness and depression, a research team sought to understand the underlying mechanisms. Loneliness is more likely to cause depression

A new study has revealed a potential reason why some pregnancies achieved through assisted reproductive technology (ART) may result in birth defects in comparison to naturally conceived pregnancies. A new Australian study has revealed a potential reason why some pregnancies achieved through assisted reproductive technology (ART) may result in birth defects in comparison to naturally

A research team improved the AI recognition accuracy of word-level sign language recognition by adding data such as the signer's hand and facial expressions, as well as skeletal information on the position of the hands relative to the body. Sign languages have been developed by nations around the world to fit the local communication style

Researchers have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and the evolution of catalytically active RNA. Researchers led by chemist Claudia Höbartner have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and

A research team proposes a method to assess cancer patients for their likelihood to either respond to treatment or relapse. Researchers from Iwate Medical University and Tohoku University have revealed that it is possible to predict cancer relapse and treatment response by measuring circulating tumor DNA (ctDNA), in tandem with data from comprehensive genomic profiling

Patients with a common aggressive type of bladder cancer could get correct treatment significantly quicker as new research suggests that initial MRI imaging and biopsy could be used to reduce the time patients wait. Patients with a common aggressive type of bladder cancer could get correct treatment significantly quicker as new research suggests that initial

A research team identified the brain's food-specific memory system and its direct role in overeating and diet-induced obesity. They found a specific population of neurons in the mouse brain that encode memories for sugar and fat, profoundly impacting food intake and body weight. Can memory influence what and how much we eat? A groundbreaking Monell

An international research team concludes that gentle touch is not only good for mental health, but also for the evolution of cooperation. The power of touch and social connections helps people to cope with an increasingly stressful world as indicated by a recent decline in mental health. Gentle, caring touch plays a significant role in